BRF2 Antibodies

AND BRF2 ELISA kits, BRF2 Proteins

Many biological assays use antibodies to detect BRF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRF2 antibodies...

We validate the specificity of these antibodies to BRF2 by testing them on tissues known to express BRF2 positively and negatively. Browse below to find the BRF2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BRF2 Infographic by Boster Bio

All BRF2 Products

Product

Figures

Specificity

Applications

Price

BRF2 (NM_018310) Human Recombinant Protein

$1249
Cat # PROTQ9HAW0
20 µg

BRF2 (NM_018310) Human Over-expression Lysate

Human

$628
Cat # LS055290
100 µg

BRF2 Overview

Facts about Transcription factor IIIB 50 kDa subunit.

BRF2 3D structure. Source: alphafold

Transcription factor IIIB 50 kDa subunit (BRF2)

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071).

Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071).

Gene Information

Human
Gene Name:	BRF2
Uniprot:	Q9HAW0
Entrez:	55290

Family

Belongs to:

TFIIB family

Alternative Names

B-related factor 2; BRF-2; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; BRFUhTFIIIB50; FLJ11052; hBRFU; TFIIIB50RNA polymerase III transcription initiation factor BRFU; transcription factor IIB- related factor, TFIIIB50; transcription factor IIIB 50 kDa subunit

Molecular Weight

Mass (kDA):
46.533 kDA

Genomic Context


Human

Location:	8p11.23
Sequence:	8; NC_000008.11 (37843268..37849861, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Mammary Neoplasms
Malignant Neoplasm Of Breast
Retinoblastoma
Malignant Tumor Of Cervix
Malignant Squamous Cell Neoplasm
Carcinoma, Transitional Cell
Neoplasm Metastasis
Uterine Cervical Neoplasm
Malignant Neoplasm Of Lung
Carcinoma In Situ

Dysplasia
Ovarian Neoplasm
Colorectal Cancer
Sporadic Breast Carcinoma
Bladder Neoplasm
Adenocarcinoma
Cell Transformation, Neoplastic

Pathways

Translation
Snrna Transcription
Cell Proliferation
Rna Processing
Dna Repair
Localization
Rna Splicing
Fermentation
Cell Cycle

Cell Growth
Mrna Processing
Chromosome Organization
Rna Interference

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRF2

References

PMID: 11040218 by Schramm L., et al. Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters.

PMID: 11121026 by Teichmann M., et al. A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements.