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BRCC3 Antibodies
AND BRCC3 ELISA kits, BRCC3 Proteins
Many biological assays use antibodies to detect BRCC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRCC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRCC3 antibodies...
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BRCC3 Infographic by Boster Bio
All BRCC3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M04690
100 µl
Cat # M04690
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04690-1
100 μg/vial
Cat # A04690-1
100 μg/vial
BRCC3 Overview
Facts about Lys-63-specific deubiquitinase BRCC36.
Lys-63-specific deubiquitinase BRCC36 (BRCC3)
Does not have action toward'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes'Lys-63'-connected ubiquitinated histones H2A and H2AX in DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).
In the BRCA1-A complex, it specifically removes'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves'Lys-63'-linked ubiquitin in a variety of substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665).
Gene Information
| Human | |
|---|---|
| Gene Name: | BRCC3 |
| Uniprot: | P46736 |
| Entrez: | 79184 |
Family
| Belongs to: |
|---|
| peptidase M67A family |
Alternative Names
BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex, subunit 3; BRCA1-A complex subunit BRCC36; BRCC36C6.1ACXorf53; BRISC complex subunit BRCC36; c6.1A; chromosome X open reading frame 53; EC 3.1.2.15; EC 3.4.19.-; lys-63-specific deubiquitinase BRCC36
Molecular Weight
Mass (kDA):
36.072 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq28 |
| Sequence: | X; NC_000023.11 (155071403..155126766) |
Tissue Specificity
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:20656690, PubMed:26344097). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm (PubMed:20656690).
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Ovarian Neoplasm
- Malignant Neoplasm Of Ovary
- Aneurysm
- Coronary Heart Disease
- Embryonal Carcinoma
- Down Syndrome
- Neoplasms, Germ Cell And Embryonal
- Carcinoma
Interacting Proteins
- ABRAXAS1
Pathways
- Dna Repair
- Cell Cycle
- Localization
- Methylation
- Dna Methylation
- Cell Proliferation
- Cell Death
- Dna Hypomethylation
PTMs
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRCC3
bosterbio.com/bosterbio-gene-info-cards/BRCC3
References
PMID: 1303175 by Kenwrick S., et al. Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene.
PMID: 8247530 by Fisch P., et al. The chromosomal translocation t(X;14)(q28;q11) in T-cell pro- lymphocytic leukaemia breaks within one gene and activates another.