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- Table of Contents
Facts about Polycomb complex protein BMI-1.
The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, also contains action only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). From the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Human | |
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Gene Name: | BMI1 |
Uniprot: | P35226 |
Entrez: | 648 |
Belongs to: |
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No superfamily |
B lymphoma Mo-MLV insertion region 1 homolog (mouse); B lymphoma Mo-MLV insertion region 1 homolog; BMI1 polycomb ring finger oncogene; BMI1; BMI-1; FLVI2/BMI1; MGC12685; murine leukemia viral (bmi-1) oncogene homolog; PCGF4; polycomb complex protein BMI-1; polycomb group protein Bmi1; polycomb group ring finger 4; RING finger protein 51; RNF51; RNF51Polycomb group RING finger protein 4
Mass (kDA):
36.949 kDA
Human | |
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Location: | 10p12.2 |
Sequence: | 10; NC_000010.11 (22321099..22331484) |
Nucleus. Cytoplasm.
PMID: 8268912 by Alkema M.J., et al. Characterization and chromosomal localization of the human proto- oncogene BMI-1.
PMID: 8390036 by Levy L.S., et al. flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1.