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- Table of Contents
Facts about Bone morphogenetic protein 1.
Cleaves the C-terminal propeptides of procollagen I, II and III.
Induces cartilage and bone formation.May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
Human | |
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Gene Name: | BMP1 |
Uniprot: | P13497 |
Entrez: | 649 |
Belongs to: |
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No superfamily |
BMP1; BMP-1; bone morphogenetic protein 1; EC 3.4.24; EC 3.4.24.19; FLJ44432; Mammalian tolloid protein; mTld; PCOLC; PCP; PCP2; procollagen C-endopeptidase; Procollagen C-proteinase; TLD
Mass (kDA):
111.249 kDA
Human | |
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Location: | 8p21.3 |
Sequence: | 8; NC_000008.11 (22165372..22212326) |
Ubiquitous.
Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Co-localizes with POSTN in the Golgi.
PMID: 8643539 by Li S.W., et al. The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.
PMID: 3201241 by Wozney J.M., et al. Novel regulators of bone formation: molecular clones and activities.