Bloc1s2 Antibodies

AND Bloc1s2 ELISA kits, Bloc1s2 Proteins

Many biological assays use antibodies to detect Bloc1s2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bloc1s2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bloc1s2 antibodies...

We validate the specificity of these antibodies to Bloc1s2 by testing them on tissues known to express Bloc1s2 positively and negatively. Browse below to find the Bloc1s2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Bloc1s2 Infographic by Boster Bio

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BLOC1S2 (NM_001001342) Human Recombinant Protein

$813
Cat # PROTQ6QNY1
20 µg

Bloc1s2 Overview

Facts about Biogenesis of lysosome-related organelles complex 1 subunit 2.

Biogenesis of lysosome-related organelles complex 1 subunit 2 (Bloc1s2)

Part of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity). In concert with the AP-3 complex, the BLOC-1 complex is needed to target membrane protein cargos to vesicles constructed at cell bodies for delivery to neurites and nerve terminals (PubMed:16760431, PubMed:21998198).

The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860). As part of the BORC complex may play a role in lysosomes motion and localization in the cell periphery.

Gene Information

Mouse
Gene Name:	Bloc1s2
Uniprot:	Q9CWG9
Entrez:	73689

Family

Belongs to:

BLOC1S2 family

Alternative Names

biogenesis of lysosomal organelles complex-1, subunit 2; BLOC-1 subunit 2; CEAP; centrosomal 10 kDa protein; centrosome protein oncogene; Centrosome-associated protein; subunit 2

Molecular Weight

Mass (kDA):
16.3 kDA

Genomic Context


Mouse

Location:	19\|19 C3
Sequence:	19;

Diseases

Hermanski-pudlak Syndrome
Hereditary Diseases
Hypopigmentation Disorder
Neoplasms
Albinism
Hemorrhage
Platelet Storage Pool Deficiency
Mutation, Out-of-frame
Neurodegenerative Disorders
Schizophrenia
Glioblastoma

Malignant Paraganglionic Neoplasm
Bleeding Tendency
Albinism, Oculocutaneous
Malignant Neoplasms
Wiskott-aldrich Syndrome

Pathways

Pathogenesis
Cell Proliferation
Pigmentation
Localization
Transport
Eye Pigmentation
Membrane Fusion

Secretion
Actin Nucleation

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Bloc1s2

References

PMID: 15102850 by Starcevic M., et al. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome- related organelles complex-1 (BLOC-1).

PMID: 16760431 by Salazar G., et al. BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes.