BIRC2 Antibodies

Baculoviral IAP repeat-containing protein 2 (BIRC2)

Multi-functional protein which regulates not just caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, in addition to cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.

Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively called pattern recognition receptors (PRRs).

Gene Information

Human
Gene Name:	BIRC2
Uniprot:	Q13490
Entrez:	329

Family

Belongs to:
IAP family

Alternative Names

API1Hiap-2; apoptosis inhibitor 1; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing protein 2; BIRC2; cIAP1; c-IAP1; cIAP-1; hIAP2; HIAP-2; IAP homolog B; IAP2; IAP-2; Inhibitor of apoptosis protein 2; MIHB; MIHBHIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RNF48hiap-2; TNFR2-TRAF-signaling complex protein 2

Molecular Weight

Mass (kDA):
69.9 kDA

Genomic Context

Human
Location:	11q22.2
Sequence:	11; NC_000011.10 (102347182..102378670)

Tissue Specificity

Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

Subcellular Localizations

Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Leukemia
• Lymphoma
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Malignant Squamous Cell Neoplasm
• Myeloid Leukemia
• Inflammation
• Esophageal Neoplasms
• Tissue Adhesions
• Malignant Tumor Of Colon

• Carcinogenesis
• Adenocarcinoma
• Leukemia, Myelocytic, Acute
• Malignant Neoplasm Of Breast
• Malignant Neoplasm Of Esophagus
• Lung Neoplasms
• Melanoma

Interacting Proteins

• BIRC7
• BOLA1
• CASP7
• CASP9
• DIABLO

• EAF2
• EXOSC5
• GCC1
• GFAP
• NMB

• OTUB1
• PPM1K
• RAC1
• RIPK1
• RIPK2

• RIPK3
• RIPK4
• TNFRSF12A
• TRAF1
• TRAF2

• TSGA10
• WDYHV1

Pathways

• Cell Death
• Programmed Cell Death
• Cell Cycle
• Localization
• Cell Growth
• Pathogenesis
• Translation
• Nuclear Export
• Oncogenesis
• Induction Of Apoptosis
• Rna Interference
• Apoptotic Process
• Cell Differentiation

• Cell Proliferation
• Regeneration
• Gene Silencing
• Inflammatory Response
• Mitosis
• Protein Stabilization
• Secretion

PTMs

• Phosphorylation
• Cleavage
• Ubiquitination

• Sumoylation
• Dephosphorylation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BIRC2

Best Uses Of The BIRC2 Marker

Are you interested in knowing more about Steven Boster and his work? Check out the following article for more information about His research primary antibodies, his research, and informationgraphics about the gene. The BIRC2 marker is a useful tool for scientists and researchers across all fields. Making use of it as a genetic marker for cancer research is especially useful. Researchers can get information on cancer on the Boster website.

His research

His research on the BIRC2 marker could aid in understanding the role this gene plays in the development of cancer. The gene is expressed differently in cells in vitro and in live cells. Further in vitro studies could help us to understand how the gene regulates the cells inside and outside of cells. Furthermore, his findings may help develop more effective treatments for FA-HNSCCs. The next step in BIRC2 research is to determine if it has a tumor suppressor role.

The BIRC2 gene is responsible for the regulation of 38 genes. It is believed to prevent cell suicide by blocking the action of apoptosis which is a method of programmed cell death. BIRC2 also inhibits the secretion of immune cells and regulates the function of other genes involved in cell growth. This is why BIRC2 is a key marker in the treatment of cancer.

His primary antibodies

BIRC2 is a genetic marker present in a wide variety of organisms. It is an essential element of human genomes since it regulates a wide range of processes. The marker can be used to test the activity of genes in a variety of tissues. This gene is present in both male and feminine reproductive organs. It regulates cell division and growth. This marker is a common genetic marker for breast cancer. It is frequently used to determine the activity of the receptor for B-cell growth hormone.

His gene infographics

His gene infographics are graphic representations of scientific data. They are designed to swiftly and clearly communicate complicated information. The Genetic Literacy Project uses infographics to communicate basic understanding of genetics and biotechnology. Their infographics and information provide educators and the general public with a valuable resource. A variety of resources are available to complement the information in infographics. Some examples are given below. The links below will lead you to more detailed explanations and details.