BICD2 Antibodies

AND BICD2 ELISA kits, BICD2 Proteins

Many biological assays use antibodies to detect BICD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BICD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BICD2 antibodies...

We validate the specificity of these antibodies to BICD2 by testing them on tissues known to express BICD2 positively and negatively. Browse below to find the BICD2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BICD2 Infographic by Boster Bio

All BICD2 Products

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Anti-Protein bicaudal D homolog 2 BICD2 Antibody

Human, Mouse, Rat

ELISA, WB

$449
Cat # A04406
0.1 mg

BICD2 (NM_015250) Human Over-expression Lysate

Human

$960
Cat # LS023299
100 µg

BICD2 Overview

Facts about Protein bicaudal D homolog 2.

BICD2 3D structure. Source: alphafold

Protein bicaudal D homolog 2 (BICD2)

Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive into a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the trail ) (By similarity).

Facilitates the binding of RAB6A into the Golgi by stabilizing its GTP-bound form. Regulates coat complicated coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruiting of this dynein-dynactin motor complex (PubMed:25962623).

Gene Information

Human
Gene Name:	BICD2
Uniprot:	Q8TD16
Entrez:	23299

Family

Belongs to:

BicD family

Alternative Names

bicaudal D homolog 2 (Drosophila); KIAA0699

Molecular Weight

Mass (kDA):
93.533 kDA

Genomic Context


Human

Location:	9q22.31
Sequence:	9; NC_000009.12 (92711363..92764841, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Golgi apparatus. Cytoplasm, cytoskeleton. Cytoplasm. Nucleus envelope. Nucleus, nuclear pore complex. In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (PubMed:20386726).

Diseases

Classical Lissencephaly
Lissencephaly
Sclerosis
Polycystic Kidney Diseases
Primary Lateral Sclerosis
Nerve Degeneration
Kidney Diseases

Chimera Disorder
Amyotrophic Lateral Sclerosis

Interacting Proteins

PMF1
RANBP2

Pathways

Transport
Localization
Cell Cycle
G2 Phase
Mitosis
Male Meiosis
Glycosylation
Microtubule-based Transport
Prophase

Interphase
Meiosis
Rna Interference
Secretion

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BICD2

References

PMID: 11864968 by Holland P.M., et al. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2.

PMID: 20386726 by Splinter D., et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.