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- Table of Contents
Facts about Class E basic helix-loop-helix protein 40.
Both these loops are interlocked because it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the action of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1.
Human | |
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Gene Name: | BHLHE40 |
Uniprot: | O14503 |
Entrez: | 8553 |
Belongs to: |
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No superfamily |
basic helix-loop-helix domain containing, class B, 2; basic helix-loop-helix family, member e40; bHLHb2; bHLHe40; Class B basic helix-loop-helix protein 2; class E basic helix-loop-helix protein 40; DEC1HLHB2; differentially expressed in chondrocytes 1; Differentially expressed in chondrocytes protein 1; differentiated embryo chondrocyte expressed gene 1; Enhancer-of-split and hairy-related protein 2; SHARP2; SHARP-2; Stimulated by retinoic acid gene 13 protein; STRA13FLJ99214; Stra14
Mass (kDA):
45.51 kDA
Human | |
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Location: | 3p26.1 |
Sequence: | 3; NC_000003.12 (4979420..4985323) |
Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
Cytoplasm. Nucleus. Predominantly localized in the nucleus (PubMed:11278694).
PMID: 9240428 by Shen M., et al. Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.
PMID: 11226878 by Teramoto M., et al. Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2.