BEND3 Antibodies

AND BEND3 ELISA kits, BEND3 Proteins

Many biological assays use antibodies to detect BEND3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BEND3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BEND3 antibodies...

We validate the specificity of these antibodies to BEND3 by testing them on tissues known to express BEND3 positively and negatively. Browse below to find the BEND3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BEND3 Infographic by Boster Bio

All BEND3 Products

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Specificity

Applications

Price

BEND3 (NM_001080450) Human Recombinant Protein

$813
Cat # PROTQ5T5X7
20 µg

BEND3 (NM_001080450) Human Over-expression Lysate

Human

$960
Cat # LS057673
100 µg

BEND3 Overview

Facts about BEN domain-containing protein 3.

BEND3 3D structure. Source: alphafold

BEN domain-containing protein 3 (BEND3)

Transcriptional repressor which partners with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of this NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909).

Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) into major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671).

Gene Information

Human
Gene Name:	BEND3
Uniprot:	Q5T5X7
Entrez:	57673

Family

Belongs to:

No superfamily

Alternative Names

BEN domain containing 3; BEN domain-containing protein 3; KIAA1553; RP11-59I9.2

Molecular Weight

Mass (kDA):
94.475 kDA

Genomic Context


Human

Location:	6q21
Sequence:	6; NC_000006.12 (107065181..107115515, complement)

Tissue Specificity

Expressed at least in heart, kidney, liver, ovary and spleen, with highest levels in spleen and lowest in heart. Expressed on the surface of T-cells.

Subcellular Localizations

Nucleus. Nucleus, nucleolus. In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation.

Diseases

Tissue Adhesions
Diabetes Mellitus
Hyperglycemia
Brain Ischemia
Hyperhomocysteinemia
Hypoxia
Immunologic Deficiency Syndromes
Tumor Angiogenesis
Malignant Neoplasms
Severe Combined Immunodeficiency
Lupus Erythematosus, Systemic
Traction Injury

Lymphoma
Arthritis, Infectious
Hemangioendothelioma
Retinal Diseases
Cold Intolerance
Pathologic Neovascularization
Retinal Neovascularization

Interacting Proteins

FAM161A
MORN4

Pathways

Transport
Endocytosis
Pathogenesis
Receptor-mediated Endocytosis
Cell Activation
Cell Migration
Induction Of Apoptosis
Glycosylation
Complement Activation
Oxidative Phosphorylation
Cell Cycle Arrest
Leukocyte Migration
Endothelial Cell Migration

Dna Replication
Chemotaxis
Drug Transport
Cell Motility
Cell Death
Cell Cycle
Endothelial Cell Chemotaxis

PTMs

Sumoylation

Glycosylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BEND3

References

PMID: 21914818 by Sathyan K.M., et al. A BEN-domain-containing protein associates with heterochromatin and represses transcription.

PMID: 25400923 by Shiheido H., et al. Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8.