RNF213 Antibodies

AND RNF213 ELISA kits, RNF213 Proteins

Many biological assays use antibodies to detect RNF213, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF213 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF213 antibodies...

We validate the specificity of these antibodies to RNF213 by testing them on tissues known to express RNF213 positively and negatively. Browse below to find the RNF213 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF213 Infographic by Boster Bio

All RNF213 Products

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C17orf27 (RNF213) (NM_020954) Human Recombinant Protein

$1249
Cat # PROTQ63HN8
20 µg

C17orf27 (RNF213) (NM_020954) Human Over-expression Lysate

Human

$628
Cat # LS057674
100 µg

RNF213 Overview

Facts about E3 ubiquitin-protein ligase RNF213.

E3 ubiquitin-protein ligase RNF213 (RNF213)

E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved from the non-canonical Wnt signaling pathway in vascular growth: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and encouraging vessel regression (PubMed:26766444).

Also has ATPase activity (PubMed:24658080, PubMed:26126547). .

Gene Information

Human
Gene Name:	RNF213
Uniprot:	Q63HN8
Entrez:	57674

Family

Belongs to:

AAA ATPase family

Alternative Names

ALK lymphoma oligomerization partner on chromosome 17; C17orf27; chromosome 17 open reading frame 27; DKFZp762N1115; FLJ13051; KIAA1554MGC46622; KIAA1618; MGC9929; NET57; protein ALO17; ring finger protein 213

Molecular Weight

Mass (kDA):
591.407 kDA

Genomic Context


Human

Location:	17q25.3
Sequence:	17; NC_000017.11 (80260820..80398794)

Tissue Specificity

Widely expressed (at protein level).

Subcellular Localizations

Cytoplasm, cytosol.

Diseases

Moyamoya Disease
Vascular Diseases
Cerebrovascular Disorders
Aneurysm
Stenosis
Infarction
Granuloma, Plasma Cell
Endometrial Polyp
Other Cerebrovascular Disease
Myeloid Leukemia, Chronic
Carotid Stenosis
Malignant Neoplasms

Head And Neck Neoplasms
Cerebral Infarction
Hemorrhage
Neoplasms
Myeloid Leukemia
Inflammatory Myofibroblastic Tumor
Lymphoma

Interacting Proteins

GOLGA2
KRT40
REL
TRIM23
TRIM27

TRIP6
UBXN11

Pathways

Pathogenesis
Estrus
Insemination

PTMs

Ubiquitination

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF213

References

PMID: 21799892 by Liu W., et al. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development.

PMID: 12112524 by Cools J., et al. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.