SH2B adapter protein 3 Antibodies

AND SH2B3 ELISA kits, SH2B adapter protein 3 Proteins

Many biological assays use antibodies to detect SH2B adapter protein 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH2B adapter protein 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH2B adapter protein 3 antibodies...

We validate the specificity of these antibodies to SH2B adapter protein 3 by testing them on tissues known to express SH2B3 positively and negatively. Browse below to find the SH2B3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SH2B3 Infographic by Boster Bio

All SH2B3 Products

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Product

Figures

Specificity

Applications

Price

Anti-SH2B adapter protein 3 SH2B3 Antibody

Human

ELISA, WB

$380
Cat # A03806
100ul

Anti-LNK (SH2B3) Mouse Monoclonal Antibody [Clone ID: OTI2D8]

Human

Flow Cytometry, IF, IHC, WB

$523
Cat # M03806
100 µl

LNK (SH2B3) (NM_005475) Human Over-expression Lysate

Human

$960
Cat # LS010019
100 µg

SH2B3 Overview

Facts about SH2B adapter protein 3.

SH2B3 3D structure. Source: alphafold

SH2B adapter protein 3 (SH2B3)

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. .

Gene Information

Human
Gene Name:	SH2B3
Uniprot:	Q9UQQ2
Entrez:	10019

Family

Belongs to:

SH2B adapter family

Alternative Names

IDDM20; LNK; LNKSH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; SH2B adaptor protein 3; SH2B3; Signal transduction protein Lnk

Molecular Weight

Mass (kDA):
63.225 kDA

Genomic Context


Human

Location:	12q24.12
Sequence:	12; NC_000012.12 (111405107..111451623)

Tissue Specificity

Preferentially expressed by lymphoid cell lines.

Diseases

Diabetes Mellitus
Autoimmune Reaction
Celiac Disease
Diabetes Mellitus, Insulin-dependent
Autoimmune Diseases
Hypertensive Disease
Arthritis
Cardiovascular Diseases
Tissue Adhesions
Rheumatoid Arthritis
Dysequilibrium Syndrome
Myeloproliferative Disease
Autoimmunity

Sclerosis
Lupus Erythematosus, Systemic
Infarction
Myocardial Infarction
Leukemia
Thyroid Diseases
Malignant Neoplasms

Interacting Proteins

EGFR
ERBB3
KIT
MET

Pathways

Pathogenesis
Cell Adhesion
Immune Response
Aging
Response To Lipopolysaccharide
Actin Cytoskeleton Organization
Cell Activation
Cell Proliferation
Cell Migration
Endothelial Cell Activation
Platelet Activation
Complement Activation
Glomerular Filtration

Glucose Homeostasis
Regeneration
Cytoskeleton Organization
Mrna Splicing
Cell Death
Cell Growth
Rna Interference

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH2B3

References

PMID: 10799879 by Li Y., et al. Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation.

PMID: 17554260 by Todd J.A., et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.