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- Table of Contents
Facts about Bcl-2-related protein A1.
Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). .
Human | |
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Gene Name: | BCL2A1 |
Uniprot: | Q16548 |
Entrez: | 597 |
Belongs to: |
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Bcl-2 family |
ACC-1; ACC-2; Bcl-2 related protein A1; BCL2A1; Bcl2L5; Bcl2-L-5; BCL2L5HBPA1; Bcl-2-like protein 5; BCL2-related protein A1; Bfl-1; BFL1bcl-2-related protein A1; GRS; GRSbcl2-L-5; hematopoietic BCL2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
Mass (kDA):
20.132 kDA
Human | |
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Location: | 15q25.1 |
Sequence: | 15; NC_000015.10 (79960892..79971196, complement) |
Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.
Cytoplasm.
PMID: 7478596 by Choi S.S., et al. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.
PMID: 8605321 by Karsan A., et al. Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.