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, No Gclids
Apoptosis regulator Bcl-2 Antibodies
AND BCL2 ELISA kits, Apoptosis regulator Bcl-2 Proteins
Many biological assays use antibodies to detect Apoptosis regulator Bcl-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Apoptosis regulator Bcl-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Apoptosis regulator Bcl-2 antibodies...
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BCL2 Infographic by Boster Bio
All BCL2 Products
Product
Figures
Specificity
Applications
Price
Anti-Bcl-2 Antibody (Monoclonal, Bcl-2-100)
163 Citations 16 Q&As
Human
IHC, ICC, WB
$370
Cat # MA1004
100 μg/vial
Cat # MA1004
100 μg/vial
Anti-Bcl2 alpha Antibody Picoband®
162 Citations 16 Q&As
Human
ELISA, WB
$370
Cat # RP1003
100 μg/vial
Cat # RP1003
100 μg/vial
Anti-Bcl-2 Rabbit Monoclonal Antibody
40 Citations 16 Q&As
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00040-1
100 μl
Cat # M00040-1
100 μl
Anti-Bcl-2 Rabbit Monoclonal Antibody
39 Citations 16 Q&As
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00040-2
100 μl
Cat # M00040-2
100 μl
Anti-Bcl-2/BCL2 Antibody Picoband®
240 Citations 16 Q&As
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00040-2
100 μg/vial
Cat # A00040-2
100 μg/vial
Anti-Human Bcl-2 DyLight® 488 conjugated Antibody
21 Citations 3 Q&As
Human
Flow Cytometry
$515
Cat # A00040-Dyl488
100 μg/vial
Cat # A00040-Dyl488
100 μg/vial
Anti-Human Bcl-2 DyLight® 550 conjugated Antibody
21 Citations 14 Q&As
Human
Flow Cytometry
$515
Cat # A00040-Dyl550
100 μg/vial
Cat # A00040-Dyl550
100 μg/vial
BCL-2 Colorimetric Cell-Based ELISA Kit
1 Citations
Human, Mouse, Rat
ELISA
$480
Cat # EKC1055
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1055
1 kit, containing one 96-well plate and all necessary reagents
Mouse, Rat
ELISA
$540
Cat # EKC2056
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2056
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2362
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2362
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2363
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2363
1 kit, containing two 96-well plates and all necessary reagents
BCL2 Overview
Facts about Apoptosis regulator Bcl-2.
Apoptosis regulator Bcl-2 (BCL2)
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability.
Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria or by binding to the apoptosis-activating variable (APAF-1).
Gene Information
| Human | |
|---|---|
| Gene Name: | BCL2 |
| Uniprot: | P10415 |
| Entrez: | 596 |
Family
| Belongs to: |
|---|
| Bcl-2 family |
Alternative Names
apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl2; Bcl-2
Molecular Weight
Mass (kDA):
26.266 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.33 |
| Sequence: | 18; NC_000018.10 (63123346..63320280, complement) |
Tissue Specificity
Expressed in a variety of tissues.
Subcellular Localizations
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Diseases
- Neoplasms
- Malignant Neoplasms
- Lymphoma
- B-cell Lymphomas
- Carcinoma
- Leukemia
- Lymphoma, Follicular
- Diffuse Large B-cell Lymphoma
- Chromosomal Translocation
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
Interacting Proteins
- AMBRA1
- BAD
- Bad
- BAK1
- BAX
- BBC3
- BCAP31
- BCL2L11
- BCLAF1
- BECN1
Pathways
- Cell Death
- Cell Cycle
- Cell Proliferation
- Pathogenesis
- Induction Of Apoptosis
- Cell Growth
- Programmed Cell Death
- Cell Cycle Arrest
- Localization
- Interphase
- Autophagy
- Angiogenesis
- Methylation
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Dephosphorylation
- Reduction
- Oxidation
- Acetylation
- Phosphorothioation
- Ubiquitination
Research Areas
- Apoptosis
- Autophagy
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCL2
bosterbio.com/bosterbio-gene-info-cards/BCL2
References
PMID: 3523487 by Tsujimoto Y., et al. Analysis of the structure, transcripts, and protein products of bcl- 2, the gene involved in human follicular lymphoma.
PMID: 1508712 by Eguchi Y., et al. Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.
301 Publications of Boster Apoptosis regulator Bcl-2 Antibodies & ELISA Kits
- PubMed ID: PMID:28559975, Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glio...
- PubMed ID: PMID:28386340, Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in...
- PubMed ID: PMID:27122753, The Effects of Fasudil at Different Doses on Acute Myocardial Infarction in Rats
- PubMed ID: PMID:26464676, Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer
- PubMed ID: PMID:26191239, Effects of intracerebral hemorrhage and subsequent minimally invasive hematoma a...
- PubMed ID: PMID:26064215, Effects of PDTC on NF-κB expression and apoptosis in rats with severe acute pan...
- PubMed ID: PMID:25785006, Alpha-lipoic acid attenuates trinitrobenzene sulfonic acid-induced ulcerative co...
- PubMed ID: 10.4314/tjpr.v15i2.7, A Study on Expression and Tyrosine 705 phosphorylation of STAT3 in Focal Cerebra...
- PubMed ID: 10.4103/1673-5374.177736, Radix Ilicis Pubescentis total flavonoids combined with mobilization of bone mar...
- PubMed ID: 10.3892/or.2015.3725, Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the re...
- PubMed ID: 10.3892/ol.2013.1103, Characterization of side population cells isolated from the gastric cancer cell ...
- PubMed ID: 10.3892/mmr.2019.10208, Ghrelin regulates sepsis‑induced rat acute gastric injury
- PubMed ID: 10.3892/etm.2014.1690, Effect of ligustilide on Ang II‑induced hypertrophy in cardiomyocytes and the...
- PubMed ID: 10.3748/wjg.v11.i29.4579, Effects of garlicin on apoptosis in rat model of colitis
- PubMed ID: 10.3724/SP.J.1009.2011.00450, Neuroprotective Effects of Hyperoside on Sodium Azide-Induced Apoptosis in PC12 ...
- PubMed ID: 10.3389/fphar.2017.00691, Protective Effects of Sodium (±)-5-Bromo-2-(α-Hydroxypentyl) Benzoate in a Rod...
- PubMed ID: 10.3389/fphar.2017.00044, Celastrol Attenuates Multiple Sclerosis and Optic Neuritis in an Experimental Au...
- PubMed ID: 10.3389/fcell.2021.684857, Tunicamycin Induces Hepatic Stellate Cell Apoptosis Through Calpain-2/Ca2 +-Depe...
- PubMed ID: 10.3109/15376516.2014.970680, Mitochondrial- and Fas-L-mediated pathways involved in quinestrol induced sperma...
- PubMed ID: 10.3109/13880209.2013.802352, Protective effects of ginseng total saponins against hepatic ischemia/reperfusio...
- PubMed ID: 10.3109/13880209.2011.576348, Protective effects of Carthamus tinctorius injection on isoprenaline-induced myo...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page