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BCAS3 Antibodies
AND BCAS3 ELISA kits, BCAS3 Proteins
Many biological assays use antibodies to detect BCAS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BCAS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BCAS3 antibodies...
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BCAS3 Overview
Facts about Breast carcinoma-amplified sequence 3.
Breast carcinoma-amplified sequence 3 (BCAS3)
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge.
Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes.
Gene Information
| Human | |
|---|---|
| Gene Name: | BCAS3 |
| Uniprot: | Q9H6U6 |
| Entrez: | 54828 |
Family
| Belongs to: |
|---|
| BCAS3 family |
Alternative Names
BCAS4/BCAS3 fusion; breast carcinoma amplified sequence 3; breast carcinoma amplified sequence 4/3 fusion protein; breast carcinoma-amplified sequence 3; DKFZp686O1527; FLJ20128; GAOB1; MAAB; metastasis associated antigen of breast cancer; MGC4973; protein Maab1
Molecular Weight
Mass (kDA):
101.237 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q23.2 |
| Sequence: | 17; NC_000017.11 (60677851..61392831) |
Tissue Specificity
Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner.
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Chronic Kidney Disease
- Pathologic Neovascularization
- Kidney Failure, Chronic
- Kidney Diseases
- Desmoplastic
Interacting Proteins
- C16orf70
- CDC23
- VIM
Pathways
- Angiogenesis
- Transport
- Cell Migration
- Cellular Process
- Dna Methylation
- Tube Formation
- Dna Repair
- Glomerular Filtration
- Methylation
- Cell Cycle
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCAS3
bosterbio.com/bosterbio-gene-info-cards/BCAS3
References
PMID: 12378525 by Baerlund M., et al. Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.
PMID: 16099728 by Siva K., et al. Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis.