BBS7 Antibodies

AND BBS7 ELISA kits, BBS7 Proteins

Many biological assays use antibodies to detect BBS7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BBS7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BBS7 antibodies...

We validate the specificity of these antibodies to BBS7 by testing them on tissues known to express BBS7 positively and negatively. Browse below to find the BBS7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BBS7 Infographic by Boster Bio

All BBS7 Products

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BBS7 (NM_018190) Human Recombinant Protein

$813
Cat # PROTQ8IWZ6
20 µg

BBS7 (NM_018190) Human Over-expression Lysate

Human

$628
Cat # LS055212
100 µg

BBS7 Overview

Facts about Bardet-Biedl syndrome 7 protein.

BBS7 3D structure. Source: alphafold

Bardet-Biedl syndrome 7 protein (BBS7)

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.

Gene Information

Human
Gene Name:	BBS7
Uniprot:	Q8IWZ6
Entrez:	55212

Family

Belongs to:

No superfamily

Alternative Names

Bardet-Biedl syndrome 7; BBS2L1Bardet-Biedl syndrome 7 protein; BBS2-like 1; BBS2-like protein 1; FLJ10715

Molecular Weight

Mass (kDA):
80.353 kDA

Genomic Context


Human

Location:	4q27
Sequence:	4; NC_000004.12 (121824329..121870497, complement)

Tissue Specificity

Isoform 2 is ubiquitously expressed. Isoform 1 is expressed in retina, lung, liver, testis, ovary, prostate, small intestine, liver, brain, heart and pancreas.

Subcellular Localizations

Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.

Diseases

Bardet-biedl Syndrome
Polydactyly
Obesity
Diabetes Mellitus
Dystrophy
Hypogonadism
Congenital Heart Defects
Retinitis Pigmentosa
Hypertensive Disease
Retinal Dystrophies
Kaufman-mckusick Syndrome

Developmental Disabilities
Retinal Diseases
Impaired Cognition
Retinal Degeneration
Cardiomyopathies
Visual Impairment

Interacting Proteins

ALDOB
BBS1
BBS10
BBS12
BBS2

CCT2
IQCB1
JUN

Pathways

Transport
Intraflagellar Transport
Pathogenesis
Translation
Melanosome Transport
Pigmentation
Membrane Biogenesis
Nuclear Export

Limb Development
Tissue Homeostasis

PTMs

Acetylation

Research Areas

Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BBS7

References

PMID: 12567324 by Badano J.L., et al. Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2.

PMID: 16327777 by Badano J.L., et al. Dissection of epistasis in oligogenic Bardet-Biedl syndrome.