BARD1 Antibodies

BRCA1-associated RING domain protein 1 (BARD1)

E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of'Lys-6'-linked polyubiquitin chains and coordinates a wide range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability.

Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that's required for its tumor suppressor function.

Gene Information

Human
Gene Name:	BARD1
Uniprot:	Q99728
Entrez:	580

Family

Belongs to:
No superfamily

Alternative Names

BARD-1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; EC 6.3.2.-

Molecular Weight

Mass (kDA):
86.648 kDA

Genomic Context

Human
Location:	2q35
Sequence:	2; NC_000002.12 (214725645..214809683, complement)

Subcellular Localizations

Nucleus. During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Malignant Neoplasm Of Ovary
• Ovarian Neoplasm
• Carcinoma
• Genotoxic Stress
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Genomic Instability
• Carcinogenesis
• Sporadic Breast Carcinoma

• Brca1 Gene Mutation
• Endometrial Polyp
• Uterine Cervical Neoplasm
• Neuroblastoma
• Epithelial Ovarian Cancer
• Animal Mammary Neoplasms
• Colorectal Cancer

Interacting Proteins

• BRCA1
• CEP126
• CEP70
• CHD3
• CSTF1

• CSTF2
• EXOC5
• FAM9B
• GIT1
• GOLGA2

• KAT7
• KRT40
• LDOC1
• PARN
• PIN1

• TCERG1

Pathways

• Dna Repair
• Cell Cycle
• Localization
• S Phase
• Nuclear Export
• Cell Cycle Checkpoint
• Dna Replication
• Mitosis
• Proteolysis
• Cell Proliferation
• Cell Death
• Double-strand Break Repair
• Cell Growth

• Rna Processing
• Protein Ubiquitination
• Dna Damage Checkpoint
• Centrosome Duplication
• Microtubule Nucleation
• Mrna Processing
• Nuclear Import

PTMs

• Ubiquitination
• Phosphorylation
• Cleavage

• Dephosphorylation
• Demethylation
• Sumoylation

• Methylation

Research Areas

• Breast Cancer
• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BARD1

Boster Bio - Best Uses Of The BARD1 Marker

Flow cytometry can be utilized in many areas of science. The method involves using particles or cells to collect samples. There are many different primary antibodies including monoclonal or polyclonal ones made by Boster Bio. These antibodies have been used for over 25 years and continue to receive the citations. They are also available in various forms and are extremely specific for the BARD1 marker.

GC

A surrogate marker, or any combination of markers, can be used to detect the BARD1 Cys557Ser variant in the genome of a person. Any of the markers listed in Table 4 can be used as a surrogate marker.

ADAM12

The BARD1 marker has several applications. It is a powerful instrument to detect the presence of specific proteins, and is among the most frequently used. It is involved in many different functions in the body, including damage signaling and protein localization. The antibody used for detection is extremely specific and can be used to identify proteins that cause cancer. However, it has certain limitations. To find out more about its benefits, read on!

TFF1

In a recent study, urinary levels of the BARD1 marker were significantly higher in patients with GC than healthy subjects. The levels were not related to H. Pylori infections. Furthermore these biomarkers are effective in detecting GC in female and HC patients. This study also demonstrated that these biomarkers are highly sensitive to stage I GC and the results of subsequent studies are awaiting.

One of the most significant proteins involved in DNA damage is the BARD1 marker. Two BRCT repeats are located at the C-terminus of the protein, which allows for interactions with other proteins within cells. These repeats can aid in identifying cells with BRCA1 mutations. Furthermore, BARD1 is involved in regulating cell growth and DNA repair. The Best Uses of the BARD1 Marker