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- Table of Contents
2 Citations 4 Q&As
2 Citations
Facts about Bcl-2 homologous antagonist/killer.
This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. .
Human | |
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Gene Name: | BAK1 |
Uniprot: | Q16611 |
Entrez: | 578 |
Belongs to: |
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Bcl-2 family |
Apoptosis regulator BAK; BAK; BAK1; BAK-LIKE; BAKMGC3887; BCL2-antagonist/killer 1; BCL2L7; bcl2-L-7; BCL2L7bcl-2 homologous antagonist/killer; BCL2-like 7 protein; Bcl-2-like protein 7; CDN1; MGC117255; pro-apoptotic protein BAK
Mass (kDA):
23.409 kDA
Human | |
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Location: | 6p21.31 |
Sequence: | 6; NC_000006.12 (33572552..33580296, complement) |
Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Mitochondrion outer membrane; Single-pass membrane protein.
The BAK1 marker is a protein located on the anti-progesterone receptor (PR) of mammalian cells. It is a significant indicator of progestin dependence, and is essential to the effective testing of pharmaceuticals and other health products. Boster Bio has just released BAK1, a new protein that can be utilized in various types of biological and chemical research.
The anti-progesterone receptor (PR) is a key treatment for cancer. These molecules are involved in the regulation of the mammary gland's hormones. These include progesterone and estrogen. It is a powerful tumor suppressor. But how does it work? We will discuss two ways to look at the mechanism behind progesterone's action.
Previously, bioassays of the past that were used in steroid analogues relied on the effects in vivo of progestins. This project developed a new bioassay based on the production in uterine cells of rabbits of a 42-kilodalton protein. This response is specific to progesterone receptor-mediated events. Synthetic anti-progestins block the response. The study needed one rabbit, which yields enough cells to measure thirty doses of test.
Anti-progestins showed early clinical potential. Hepatotoxicities hindered their effectiveness. This could be the result of cross-reactivity between nuclear receptors. The PR could also work to regulate specific genes in response to estrogen. If this is the case, how does it accomplish this?
A new study has shown that progesterone serves multiple purposes. It regulates immune responses as well as inhibits lactation. It also regulates blood pressure, and regulates the storage of fat. Progesterone can also prevent apoptosis (a common complication of brain injury). It blocks several enzymes that are involved in the apoptosis path, including cytochrome c and activated caspase 3.
The term hormone-regulated genes is frequently used by the authors. They should state exactly which genes they're talking about when they use the term. The authors submit their data to the NCBI Gene Expression Omnibus database under accession number GSE139398. They have however omitted this section from their manuscript. They would have seen more favorable results if they had done it.
The agonist hPRL-G129R blocks the effects of exogenous prolactin on FASN gene transcription in MCF-7/neo parental cells. In addition, the PRA and PR-B antagonists blocked the activation of the FASN gene promoter in MCF-7/HER2 breast cancer cell lines.
PMID: 7715729 by Farrow S.N., et al. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K.
PMID: 7715730 by Chittenden T., et al. Induction of apoptosis by the Bcl-2 homologue Bak.
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