BRISC and BRCA1-A complex member 2 (BABAM2)

Part of the BRCA1-A complex, a complex that specifically recognizes'Lys-63'-connected ubiquitinated histones H2A and H2AX in DNA lesions websites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also owns deubiquitinase action that specifically removes'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748).

In the BRCA1-A complicated, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the remainder of the complex, thereby needing the intricate integrity and regulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Part of the BRISC complicated, a multiprotein complex that specifically cleaves'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665).