CDC42BPB Antibodies

AND CDC42BPB ELISA kits, CDC42BPB Proteins

Many biological assays use antibodies to detect CDC42BPB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDC42BPB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDC42BPB antibodies...

We validate the specificity of these antibodies to CDC42BPB by testing them on tissues known to express CDC42BPB positively and negatively. Browse below to find the CDC42BPB antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CDC42BPB Infographic by Boster Bio

All CDC42BPB Products

Product

Figures

Specificity

Applications

Price

Anti-MRCKB CDC42BPB Antibody

5 Q&As

Human, Mouse, Rat

IHC, WB

$360
Cat # A07454
100 µl

CDC42 Binding Protein Kinase Beta (CDC42BPB) (NM_006035) Human Over-expression Lysate

Human

$960
Cat # LS009578
100 µg

CDC42BPB Overview

Facts about Serine/threonine-protein kinase MRCK beta.

CDC42BPB 3D structure. Source: alphafold

Serine/threonine-protein kinase MRCK beta (CDC42BPB)

Serine/threonine-protein kinase that's an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762).

In concert with MYO18A and LURAP1, is involved in regulating lamellar actomyosin retrograde flow that is imperative to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715).

Gene Information

Human
Gene Name:	CDC42BPB
Uniprot:	Q9Y5S2
Entrez:	9578

Family

Belongs to:

protein kinase superfamily

Alternative Names

CDC42 binding protein kinase beta (DMPK-like); CDC42-binding protein kinase beta (DMPK-like); CDC42-binding protein kinase beta; DMPK-like beta; EC 2.7.11; EC 2.7.11.1; FLJ37601; FLJ44730; KIAA1124DKFZp686H1431; MRCK beta; MRCKB; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Myotonic dystrophy protein kinase-like beta; serine/threonine-protein kinase MRCK beta

Molecular Weight

Mass (kDA):
194.315 kDA

Genomic Context


Human

Location:	14q32.32
Sequence:	14; NC_000014.9 (102932380..103057549, complement)

Tissue Specificity

Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cell projection, lamellipodium. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42 (PubMed:21240187). Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner (By similarity).