UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (B3galnt2)

Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a special carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate.

Involved in alpha-dystroglycan (DAG1) glycosylation: behaves coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus in the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). .