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- Table of Contents
Facts about UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2.
Involved in alpha-dystroglycan (DAG1) glycosylation: behaves coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus in the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). .
Mouse | |
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Gene Name: | B3galnt2 |
Uniprot: | Q8BG28 |
Entrez: | 97884 |
Belongs to: |
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glycosyltransferase 31 family |
B3GalNAc-T2; B3GALNT2; beta 1,3-N-acetylgalactosaminyltransferase-II (MGC39558); beta-1,3-galactosaminyltransferase 2; Beta-1,3-GalNAc-T2; beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase II; EC 2.4.1; EC 2.4.1.-; MDDGA11; MGC39558; UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2; UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 2
Mass (kDA):
57.219 kDA
Mouse | |
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Location: | 13|13 A1 |
Sequence: | 13; |
Present in testis (at protein level). In testis, it is mainly detected in the middle layers of seminiferous tubules at stages XII to II. Strongly expressed in primary and secondary spermatocytes and early round spermatids, but not in spermatogonia, elongating or elongated spermatids, or in Leydig or Sertoli cells.
PMID: 14724282 by Hiruma T., et al. A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc.