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- Table of Contents
Facts about Beta-2-microglobulin.
Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and reduces its export to the cell surface (total protein levels do not change), likely resulting in defects in class I antigen presentation (PubMed:25356553).
Human | |
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Gene Name: | B2M |
Uniprot: | P61769 |
Entrez: | 567 |
Belongs to: |
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beta-2-microglobulin family |
B2M; beta 2Microglobulin; beta 2-Microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin
Mass (kDA):
13.715 kDA
Human | |
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Location: | 15q21.1 |
Sequence: | 15; NC_000015.10 (44711492..44718877) |
Secreted. Cell surface. Detected in serum and urine (PubMed:1336137, PubMed:7554280).; (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).
PMID: 3312414 by Guessow D., et al. The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit.
PMID: 16108498 by He X.H., et al. Cloning of human beta-microglobulin gene and its high expression in Escherichia coli.