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- Table of Contents
Facts about AFG1-like ATPase.
Putative mitochondrial ATPase.
Plays a role in mitochondrial morphology and mitochondrial protein metabolism.Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and regular activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
Mouse | |
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Gene Name: | Afg1l |
Uniprot: | Q3V384 |
Entrez: | 215951 |
Belongs to: |
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AFG1 ATPase family |
AFG1-like ATPase
Mass (kDA):
54.313 kDA
Mouse | |
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Location: | 10 B2|10 22.88 cM |
Sequence: | 10; |
Highly expressed in heart, kidney, and lactating breast. Present at reduced levels in virgin, pregnant, and involuting breast.
PMID: 12079282 by Abrahams B.S., et al. Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci.