AEN Antibodies

AND AEN ELISA kits, AEN Proteins

Many biological assays use antibodies to detect AEN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AEN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AEN antibodies...

We validate the specificity of these antibodies to AEN by testing them on tissues known to express AEN positively and negatively. Browse below to find the AEN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AEN Infographic by Boster Bio

All AEN Products

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Apoptosis enhancing nuclease (AEN) (NM_022767) Human Recombinant Protein

$813
Cat # PROTQ8WTP8
20 µg

Apoptosis enhancing nuclease (AEN) (NM_022767) Human Over-expression Lysate

Human

$628
Cat # LS064782
100 µg

AEN Overview

Facts about Apoptosis-enhancing nuclease.

AEN 3D structure. Source: alphafold

Apoptosis-enhancing nuclease (AEN)

Exonuclease with action against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis.

When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. .

Gene Information

Human
Gene Name:	AEN
Uniprot:	Q8WTP8
Entrez:	64782

Family

Belongs to:

No superfamily

Alternative Names

apoptosis enhancing nuclease; EC 3.1; EC 3.1.13.1; FLJ12484; FLJ12562; interferon stimulated exonuclease gene 20kDa-like 1; Interferon-stimulated 20 kDa exonuclease-like 1; ISG20L1apoptosis-enhancing nuclease; pp12744

Molecular Weight

Mass (kDA):
36.35 kDA

Genomic Context


Human

Location:	15q26.1
Sequence:	15; NC_000015.10 (88604601..88632281)

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.

Diseases

Esophageal Necrotic Lesion
Hemorrhage
Hypertensive Disease
Neoplasms
Gastrointestinal Hemorrhage
Liver Neoplasms
Bradycardia
Liver Carcinoma
Esophageal Diseases
Malnutrition
Pain
Apnea

Esophagitis
Upper Gastrointestinal Hemorrhage
Disease Of Adrenal Medulla
Liver Cirrhosis
Liver Diseases
Nasopharyngeal Diseases
Vascular Diseases

Interacting Proteins

AAMP
AES
EMD
EXOSC8
GNPTAB

IKZF1
KHDRBS2
KRT40
KRTAP10-5
KRTAP10-7

KRTAP10-8
LZTS2
MTUS2
PDE4DIP
PHC2

RALYL
RBMY1A1
RBMY1F
RPGRIP1
SSX2IP

TRIM27
TRIM41
ZBTB43
ZBTB8A
ZFP64

ZNF317
ZNF473

Pathways

Enucleation
Regeneration
Localization
Reflex
Cell Proliferation
Induction Of Apoptosis
Dna Repair
Platelet Activation
Pigmentation
Platelet Aggregation
Ribosome Biogenesis

Fermentation
Cell Death
Cell Cycle
Vasoconstriction
Innervation
Autophagy

PTMs

Nitration
Cleavage

Phosphorylation
Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AEN

References

PMID: 16171785 by Lee J.-H., et al. Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis.

PMID: 18264133 by Kawase T., et al. p53 target gene AEN is a nuclear exonuclease required for p53- dependent apoptosis.