This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
ACKR1 Antibodies
AND ACKR1 ELISA kits, ACKR1 Proteins
Many biological assays use antibodies to detect ACKR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACKR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACKR1 antibodies...
Previous: CCN2
Next: FYB1
ACKR1 Infographic by Boster Bio
All ACKR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04540
100 μl/vial
Cat # M04540
100 μl/vial
ACKR1 Overview
Facts about Atypical chemokine receptor 1.
Atypical chemokine receptor 1 (ACKR1)
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that's uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.
Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines such as CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.
Gene Information
| Human | |
|---|---|
| Gene Name: | ACKR1 |
| Uniprot: | Q16570 |
| Entrez: | 2532 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
ACKR1; CCBP1; CD234 antigen; CD234; DARC; Dfy; Duffy Antigen; Duffy antigen/chemokine receptor; Duffy blood group antigen; Duffy blood group, chemokine receptor; Fy Antigen; Fy glycoprotein; FYDuffy blood group; Glycoprotein D; GPD; GPDWBCQ1; GpFy; Plasmodium vivax receptor
Molecular Weight
Mass (kDA):
35.553 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.2 |
| Sequence: | 1; NC_000001.11 (159204875..159206500) |
Tissue Specificity
Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.
Subcellular Localizations
Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Diseases
- Malaria
- Inflammation
- Cell Invasion
- Malaria, Vivax
- Neoplasms
- Cholangiocarcinoma
- Malignant Neoplasms
- Hiv Infections
- Tissue Adhesions
- Neoplasm Metastasis
- Tumor Angiogenesis
- Substance-related Disorders
Interacting Proteins
- CCR5
Pathways
- Angiogenesis
- Pathogenesis
- Transcytosis
- Chemotaxis
- Immune Response
- Sensitization
- Leukocyte Migration
- Transport
- Senescence
- Cell Death
- Cell Migration
- Programmed Cell Death
- Hypersensitivity
PTMs
- Glycosylation
- Sulphation
Research Areas
- Immunology
- Innate Immunity
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACKR1
bosterbio.com/bosterbio-gene-info-cards/ACKR1
References
PMID: 8248172 by Chaudhuri A., et al. Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.
PMID: 7663520 by Tournamille C., et al. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.