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- Table of Contents
Facts about Retinal-specific phospholipid-transporting ATPase ABCA4.
May play a role in photoresponse, removing ATR/NR-PE in the extracellular photoreceptor surfaces during bleach recovery. .
Human | |
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Gene Name: | ABCA4 |
Uniprot: | P78363 |
Entrez: | 24 |
Belongs to: |
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ABC transporter superfamily |
ABC10; ABCRRMP; ARMD2DKFZp781N1972; ATP binding cassette transporter; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding transporter, retina-specific; CORD3; EC 3.6.3; FFMFLJ17534; photoreceptor rim protein; retinal-specific ATP-binding cassette transporter; retina-specific ABC transporter; RIM ABC transporter; RIM protein; RmP; RP19; Stargardt disease protein; STGD; STGD1
Mass (kDA):
255.944 kDA
Human | |
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Location: | 1p22.1 |
Sequence: | 1; NC_000001.11 (93992834..94121148, complement) |
Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.
Boster Bio anti–ABCA4 markers are available for purchase. We'll be discussing its high affinity, versatility , and optimization in this article. This article will also teach you how to use it for your own research. It will help you increase the value of your research. Before we dive into the specifics of Boster Bio's ABCA4 marker let's look at some of its potential uses.
Boster Bio's Anti-ABCA4 catalog number A01048-1 is the best choice when you are looking for an antibody to study ABCA4 protein. This monoclonal antibody works well with Rat, Mouse, and Human. It has been validated for multiple assays, including immunohistochemistry, ELISA, and flow cytometry. Researchers who want to compare levels of the protein in different tissues will find this boster bio-antibody useful.
The ABCA4 protein is a vital cellular marker used in many biological tests. The protein is present in a wide range of animal samples including mouse and human. The Boster Bio antibodies react with the protein at monoclonal and polyclonal levels. These antibodies are created by the company using mouse and rabbit models. They can be used in a variety of biological assays. Scientists can submit their research findings for specific species and applications and also receive credit for their work.
The Boster Bio's ABCA4 marker optimizer lets researchers to quickly identify diseases-causing mutations in a variety of animal species. Many bioassays find antibodies to ABCA4 in samples from mice and rabbits, zebrafish, humans, and other animals. Boster Bio utilizes rabbit and mouse to create its ABCA4 antibodies, and has proven their effectiveness in detecting disease-causing mutations.
Its application in troubleshooting can be traced back to the very first concepts and techniques of statistical analysis. Because many issues are not just due to one factor, statistical analysis can help isolate the cause of a problem. Serial substitution and other strategies can be employed to increase the frequency or occurrence of a particular symptoms. This is beneficial in the case of a single component failure. In this instance, the symptom disappearance does not necessarily mean that there is a root cause.
One of the primary advantages of troubleshooting is its ability to take time from your team. Troubleshooting is a necessary part of maintaining assets. by using detailed asset history logs you can troubleshoot your equipment on your own and free up your team to concentrate on other tasks. Performing maintenance is expensive and if your organization lacks the expertise to perform proactive troubleshooting you could end having to pay a high price for reactive maintenance. Finance departments must be aware of any the unplanned repair costs and the immediate costs associated with maintenance.
When it comes to troubleshooting, the most important thing to do is to gather information. You can then make a guess and offer solutions. Then, test your theories by using a smaller resource to see if the theory works. Even if you are presented with several options, always begin with the simplest. Troubleshooting requires in-depth knowledge of both software and hardware.
Troubleshooting is a systematic approach to find the root of the problem. The goal of troubleshooting to fix a problem and make sure your system is running in the way it should. It is also an opportunity to repair your computer, software, and process. These methods might not work for you initially, but you'll be glad that you tried these methods. It could save your time and money in the long-term.
PMID: 9054934 by Allikmets R., et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy.
PMID: 9202155 by Azarian S.M., et al. The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR).