This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Aurora kinase B Antibodies
AND AURKB ELISA kits, Aurora kinase B Proteins
Many biological assays use antibodies to detect Aurora kinase B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aurora kinase B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aurora kinase B antibodies...
Previous: CCN4
Next: XPR1
AURKB Infographic by Boster Bio
All AURKB Products
Product
Figures
Specificity
Applications
Price
Human, Monkey
ELISA, IHC, WB
$629
Cat # P00762
100ug
Cat # P00762
100ug
Human
IP, IF, IHC, ICC, WB
$370
Cat # M00762-1
100 μl
Cat # M00762-1
100 μl
Bovine, Equine, Human, Mouse, Pig, Rat
IF, IHC, WB
$299
Cat # M00246-1
100ul
Cat # M00246-1
100ul
Bovine, Equine, Human, Mouse, Pig, Rat
IHC, WB
$299
Cat # M00246-2
100ul
Cat # M00246-2
100ul
Human, Mouse, Rat
IF, IHC, WB
$299
Cat # M00246-3
100ul
Cat # M00246-3
100ul
Human, Mouse, Rat
IF, IHC, WB
$299
Cat # M00762-2
100ul
Cat # M00762-2
100ul
Bovine, Equine, Human, Mouse, Rat
IF, IHC, WB
$299
Cat # M00762-3
100ul
Cat # M00762-3
100ul
Human
IHC, WB
$431
Cat # M00762-4
100uL
Cat # M00762-4
100uL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1049
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1049
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1050
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1050
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2282
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2282
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00762T232
100ul
Cat # A00762T232
100ul
Human, Mouse, Rat
ELISA, IHC
$380
Cat # A00762T236
100ul
Cat # A00762T236
100ul
AURKB Overview
Facts about Aurora kinase B.
Aurora kinase B (AURKB)
Serine/threonine-protein kinase part of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions in the centromere in ensuring proper chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation.
Gene Information
| Human | |
|---|---|
| Gene Name: | AURKB |
| Uniprot: | Q96GD4 |
| Entrez: | 9212 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Aik2; AIK2EC 2.7.11.1; AIM1; AIM-1; AIM1Aik2; AIM-1STK-1; ARK2; ARK2ARK-2; AurB; AURKB; aurkb-sv2; Aurora- and IPL1-like midbody-associated protein 1; Aurora B; aurora kinase BSerine/threonine-protein kinase aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora/IPL1-related kinase 2; aurora-1; aurora-B; Aurora-related kinase 2; EC 2.7.11; IPL1; serine/threonine kinase 12; serine/threonine-protein kinase 12; STK12; STK12aurkb-sv1; STK5
Molecular Weight
Mass (kDA):
39.311 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (8204731..8210767, complement) |
Tissue Specificity
High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the midbody. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody. Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Aneuploidy
- Malignant Paraganglionic Neoplasm
- Carcinogenesis
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Lung
- Chromosomal Translocation
- Cell Invasion
- Malignant Neoplasm Of Prostate
- Mammary Neoplasms
Interacting Proteins
- BIRC5
- CDC37
- CDCA8
- GAS2L3
- HIST3H3
- HSP90AB1
- INCENP
- KAT5
- MAPRE1
- NPM1
Pathways
- Mitosis
- Cell Cycle
- Chromosome Segregation
- Cell Division
- Meiosis
- Cytokinesis
- Localization
- Cell Proliferation
- Metaphase
- Spindle Assembly
- Chromosome Condensation
- Dna Repair
- Oocyte Maturation
PTMs
- Phosphorylation
- Methylation
- Cleavage
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AURKB
bosterbio.com/bosterbio-gene-info-cards/AURKB
References
PMID: 9514916 by Shindo M., et al. cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
PMID: 9809983 by Tatsuka M., et al. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.