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- Table of Contents
Facts about V-type proton ATPase subunit H.
Subunit of the peripheral V1 complex of vacuolar ATPase.
Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow.Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.
Human | |
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Gene Name: | ATP6V1H |
Uniprot: | Q9UI12 |
Entrez: | 51606 |
Belongs to: |
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V-ATPase H subunit family |
ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; CGI-11; MSTP042; NBP1; Nef-binding protein 1; Protein VMA13 homolog; SFD; SFDalpha; SFDbeta; vacuolar ATP synthase subunit H; vacuolar ATPase subunit H; vacuolar proton pump H subunit; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD; V-ATPase 50/57 kDa subunits; V-ATPase H subunit; V-ATPase subunit H; VMA13; V-type proton ATPase subunit H
Mass (kDA):
55.883 kDA
Human | |
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Location: | 8q11.23 |
Sequence: | 8; NC_000008.11 (53715543..53843311, complement) |
Widely expressed.
PMID: 9620685 by Lu X., et al. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.
PMID: 12032142 by Geyer M., et al. Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.