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- Table of Contents
Facts about Golgi to ER traffic protein 4 homolog.
Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892).
Human | |
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Gene Name: | GET4 |
Uniprot: | Q7L5D6 |
Entrez: | 51608 |
Belongs to: |
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GET4 family |
CEEchromosome 7 open reading frame 20; CGI-20; golgi to ER traffic protein 4 homolog (S. cerevisiae); TRC3535kDa
Mass (kDA):
36.504 kDA
Human | |
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Location: | 7p22.3 |
Sequence: | 7; NC_000007.14 (876554..896436) |
Cytoplasm, cytosol.
PMID: 18249086 by Fernandes J.M.O., et al. Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development.
PMID: 20676083 by Mariappan M., et al. A ribosome-associating factor chaperones tail-anchored membrane proteins.