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- Table of Contents
Facts about V-type proton ATPase subunit C 2.
V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. .
Mouse | |
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Gene Name: | Atp6v1c2 |
Uniprot: | Q99L60 |
Entrez: | 68775 |
Belongs to: |
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V-ATPase C subunit family |
ATP6C2; ATPase, H+ transporting, lysosomal 42kD, V1 subunit C isoform 2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; Vacuolar proton pump subunit C 2; V-ATPase C2 subunit; V-ATPase subunit C 2; VMA5; V-type proton ATPase subunit C 2
Mass (kDA):
48.35 kDA
Mouse | |
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Location: | 12|12 A1.1 |
Sequence: | 12; |
Predominantly expressed in the lung and kidney. Isoform 1 is lung-specific while isoform 3 is a kidney- specific isoform. Isoform 1 is localized in the lamellar bodies of type II alveolar cells. Isoform 2 is strongly expressed in the cortical and medulla collecting ducts and is found in the plasma membranes of renal alpha and beta intercalated cells.
PMID: 12527205 by Sun-Wada G.-H., et al. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits.
PMID: 12947086 by Sun-Wada G.H., et al. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung.