Serine-protein kinase ATM Antibodies

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Also plays a role in pre-B cell allelic exclusion, a procedure resulting in expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes.

After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele into pericentromeric heterochromatin, preventing accessibility into the RAG complex and recombination of the second allele. Also included in signal transduction and cell cycle control.