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- Table of Contents
Facts about Cysteine protease ATG4D.
Exposure of the glycine in the C-terminus is vital for ATG8 proteins conjugation into phosphatidylethanolamine (PE) and insertion to membranes, which is essential for autophagy. Has also an activity of delipidating receptor to the PE-conjugated forms.
Human | |
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Gene Name: | ATG4D |
Uniprot: | Q86TL0 |
Entrez: | 84971 |
Belongs to: |
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peptidase C54 family |
APG4 autophagy 4 homolog D (S. cerevisiae); APG4 autophagy 4 homolog D; APG4D; APG4-D; ATG4 autophagy related 4 homolog D (S. cerevisiae); AUTL4; AUT-like 4 cysteine endopeptidase; AUT-like 4, cysteine endopeptidase (S. cerevisiae); AUT-like 4, cysteine endopeptidase; autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D; cysteine protease ATG4D; cysteine protease involved in autophagy; EC 3.4.22; EC 3.4.22.-
Mass (kDA):
52.922 kDA
Human | |
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Location: | 19p13.2 |
Sequence: | 19; NC_000019.10 (10543897..10553418) |
Mainly expressed in skeletal muscle and, to a lower extent, in testis.
[Cysteine protease ATG4D]: Cytoplasm.; [Cysteine protease ATG4D, mitochondrial]: Cytoplasm. Mitochondrion matrix. Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death.
PMID: 12446702 by Marino G., et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
PMID: 19549685 by Betin V.M., et al. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.