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- Table of Contents
Facts about Autophagy-related protein 16-1.
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Human | |
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Gene Name: | ATG16L1 |
Uniprot: | Q676U5 |
Entrez: | 55054 |
Belongs to: |
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WD repeat ATG16 family |
APG16 autophagy 16-like (S. cerevisiae); APG16L beta; APG16LFLJ10828; APG16-like 1; ATG16 autophagy related 16-like (S. cerevisiae); ATG16 autophagy related 16-like 1 (S. cerevisiae); ATG16A; ATG16L; autophagy-related protein 16-1; FLJ00045; FLJ10035; FLJ22677; IBD10; WD repeat domain 30; WDR30
Mass (kDA):
68.265 kDA
Human | |
---|---|
Location: | 2q37.1 |
Sequence: | 2; NC_000002.12 (233251571..233295674) |
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.
PMID: 15620219 by Zheng H., et al. Cloning and analysis of human Apg16L.
PMID: 17200669 by Hampe J., et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.