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- Table of Contents
Facts about Asporin.
Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal.
Human | |
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Gene Name: | ASPN |
Uniprot: | Q9BXN1 |
Entrez: | 54829 |
Belongs to: |
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small leucine-rich proteoglycan (SLRP) family |
asporin (LRR class 1); asporin; FLJ20129; OS3; periodontal ligament associated protein 1; Periodontal ligament-associated protein 1; PLAP-1; PLAP1SLRR1Casporin proteoglycan; small leucine-rich protein 1C
Mass (kDA):
43.417 kDA
Human | |
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Location: | 9q22.31 |
Sequence: | 9; NC_000009.12 (92456205..92482506, complement) |
Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage.
Secreted, extracellular space, extracellular matrix.
PMID: 11152692 by Lorenzo P., et al. Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan.
PMID: 11587855 by Yamada S., et al. Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene.