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- Table of Contents
Facts about Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein.
Unknown.
The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity..
Human | |
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Gene Name: | ASMTL |
Uniprot: | O95671 |
Entrez: | 8623 |
Belongs to: |
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No superfamily |
acetylserotonin N-methyltransferase-like; acetylserotonin O-methyltransferase-like; ASMTLX; ASMTLY; ASTML; N-acetylserotonin O-methyltransferase-like protein
Mass (kDA):
68.857 kDA
Human | |
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Location: | Xp22.33 and Yp11.2 |
Sequence: | X|Y; NC_000023.11 (1403139..1453794, complement) |
Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.
PMID: 9736779 by Ried K., et al. Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL.
PMID: 24210219 by Tchigvintsev A., et al. Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.