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- Table of Contents
Facts about Arrestin domain-containing protein 1.
More commonly, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).
Human | |
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Gene Name: | ARRDC1 |
Uniprot: | Q8N5I2 |
Entrez: | 92714 |
Belongs to: |
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arrestin family |
Arrestin domain-containing protein 1
Mass (kDA):
45.981 kDA
Human | |
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Location: | 9q34.3 |
Sequence: | 9; NC_000009.12 (137605640..137615360) |
Cell membrane. Also found in extracellular vesicles different from exosomes.
PMID: 21191027 by Rauch S., et al. Multiple interactions between the ESCRT machinery and arrestin- related proteins: implications for PPXY-dependent budding.
PMID: 22315426 by Nabhan J.F., et al. Formation and release of arrestin domain-containing protein 1- mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.