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- Table of Contents
Facts about Actin-related protein 2/3 complex subunit 4.
In addition to its function in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by encouraging nuclear actin polymerization, resulting in drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Human | |
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Gene Name: | ARPC4 |
Uniprot: | P59998 |
Entrez: | 10093 |
Belongs to: |
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ARPC4 family |
actin related protein 2/3 complex, subunit 4, 20kDa; actin-related protein 2/3 complex subunit 4; arp2/3 protein complex subunit p20; MGC13544; p20-Arc; subunit 4 (20 kD)
Mass (kDA):
19.667 kDA
Human | |
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Location: | 3p25.3 |
Sequence: | 3; NC_000003.12 (9792495..9807724) |
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
PMID: 9359840 by Machesky L.M., et al. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.
PMID: 9230079 by Welch M.D., et al. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.