ARPC3 Antibodies

AND ARPC3 ELISA kits, ARPC3 Proteins

Many biological assays use antibodies to detect ARPC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARPC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARPC3 antibodies...

We validate the specificity of these antibodies to ARPC3 by testing them on tissues known to express ARPC3 positively and negatively. Browse below to find the ARPC3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARPC3 Infographic by Boster Bio

All ARPC3 Products

Product

Figures

Specificity

Applications

Price

Anti-ARPC3 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A06874
100ul

p21 ARC (ARPC3) (NM_005719) Human Recombinant Protein

$1249
Cat # PROTO15145
20 µg

p21 ARC (ARPC3) (NM_005719) Human Over-expression Lysate

Human

$628
Cat # LS010094
100 µg

ARPC3 Overview

Facts about Actin-related protein 2/3 complex subunit 3.

ARPC3 3D structure. Source: alphafold

Actin-related protein 2/3 complex subunit 3 (ARPC3)

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation- promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).

In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double- strand breaks (DSBs) (PubMed:29925947).

Gene Information

Human
Gene Name:	ARPC3
Uniprot:	O15145
Entrez:	10094

Family

Belongs to:

ARPC3 family

Alternative Names

actin related protein 2/3 complex, subunit 3, 21kDa; subunit 3 (21 kD)

Molecular Weight

Mass (kDA):
20.547 kDA

Genomic Context


Human

Location:	12q24.11
Sequence:	12; NC_000012.12 (110434823..110450411, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection. Nucleus.

Diseases

Tissue Adhesions
Porokeratosis, Disseminated Superficial Actinic
Protrusion
Malignant Neoplasms
Neuroblastoma
Neoplasm Metastasis
Psoriasis
Malignant Neoplasm Of Breast
Abnormal Coordination
Sciatic Neuropathy

Neoplasms
Aggressive Systemic Mastocytosis
Asthma
Malignant Neoplasm Of Pancreas
Wiskott-aldrich Syndrome

Interacting Proteins

ARPC1B
ARPC4
GOLGA2
HOXA3
NRIP1

WASL

Pathways

Actin Nucleation
Cell Migration
Endocytosis
Localization
Keratinization
Establishment Of Cell Polarity
Locomotion
Cell Adhesion
Mitosis
Fibroblast Migration
Cytokinesis

Cytoskeleton Organization
Phagocytosis
Cell Cycle
Cell Motility
Pathogenesis
Meiosis

PTMs

Acetylation
Isopeptide bond

Phosphoprotein
Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARPC3

References

PMID: 9359840 by Machesky L.M., et al. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.

PMID: 9230079 by Welch M.D., et al. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.