Aquaporin-2 Antibodies

AND AQP2 ELISA kits, Aquaporin-2 Proteins

Many biological assays use antibodies to detect Aquaporin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aquaporin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aquaporin-2 antibodies...

We validate the specificity of these antibodies to Aquaporin-2 by testing them on tissues known to express AQP2 positively and negatively. Browse below to find the AQP2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: A1BG Next: ABCC6

AQP2 Infographic by Boster Bio

All AQP2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Aquaporin 2/AQP2 Antibody Picoband®

5 Citations 16 Q&As

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # PB9474
100 μg/vial

Anti-Aquaporin 2/AQP2 Antibody Picoband®

2 Citations 17 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PA1742
100 μg/vial

Anti-Phospho-Aquaporin 2 (Ser261) Antibody

16 Q&As

Human, Mouse, Rat

IP, IHC, ICC, WB

$481
Cat # P00935
100 µl

Anti-Phospho-AQP2 (S256) Antibody

Human, Mouse, Rat

ELISA, IHC

$380
Cat # A00935S256
100ul

Anti-Aqp2 Antibody Picoband®

Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A00935
100 µg/vial

AQP2 Overview

Facts about Aquaporin-2.

AQP2 3D structure. Source: alphafold

Aquaporin-2 (AQP2)

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. .

Gene Information

Human
Gene Name:	AQP2
Uniprot:	P41181
Entrez:	359

Family

Belongs to:

MIP/aquaporin (TC 1.A.8) family

Alternative Names

ADH water channel; AQP-2; AQP-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH-CD

Molecular Weight

Mass (kDA):
28.837 kDA

Genomic Context


Human

Location:	12q13.12
Sequence:	12; NC_000012.12 (49950737..49958878)

Tissue Specificity

Expressed in renal collecting tubules.

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity).

Diseases

Diabetes Mellitus
Nephrogenic Diabetes Insipidus
Disease Of Adrenal Medulla
Polyuria
Dehydration
Kidney Diseases
Deprivation Of Water
Edema
Heart Failure
Congenital Nephrogenic Diabetes Insipidus
Anti-diuresis (finding)
Kidney Failure

Inappropriate Adh Syndrome
Polydipsia
Liver Cirrhosis
Hypertensive Disease
Ureteral Obstruction
Water-electrolyte Imbalance

Pathways

Excretion
Transport
Localization
Water Transport
Secretion
Water Homeostasis
Endocytosis
Diuresis
Glomerular Filtration
Pathogenesis
Exocytosis
Natriuresis
Fluid Transport

Cellular Localization
Glycosylation
Translation
Aging
Cell Proliferation
Urea Transport
Response To Water Deprivation

PTMs

Phosphorylation
Glycosylation
Biotinylation
Dephosphorylation
Ubiquitination

Cleavage
Nitration
Reduction
Prenylation
Acylation

Myristoylation

Research Areas

Plasma Membrane Markers
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AQP2

References

PMID: 8140421 by Deen P.M.T., et al. Requirement of human renal water channel aquaporin-2 for vasopressin- dependent concentration of urine.

PMID: 7522228 by Uchida S., et al. Isolation of human aquaporin-CD gene.

5 Publications of Boster Aquaporin-2 Antibodies & ELISA Kits

PubMed ID: 10.1111/j.1440-1681.2011.05481.x, Effect of exercise training on renal function and renal aquaporin‐2 expression...
PubMed ID: 10.1080/01443615.2017.1327516, Expression and significance of aquaporin-2 and serum hormones in placenta of pat...
PubMed ID: 10.1016/j.transproceed.2010.02.070, The Changes of Aquaporin 2 in the Graft of Acute Rejection Rat Renal Transplanta...
PubMed ID: 26261083, Expression pattern of aquaporins in patients with primary nephrotic syndrome wit...
PubMed ID: 21824173, Cui Wy, Tian Ay, Bai T. Clin Exp Pharmacol Physiol. 2011 Nov;38(11):747-54. Doi:...

*More publications can be found for each product on its corresponding product page