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- Table of Contents
Facts about DNA dC->dU-editing enzyme APOBEC-3B.
The resultant detrimental levels of mutations from the proviral genome, along with a deamination- independent mechanism that operates before the proviral integration, together exert efficient antiretroviral effects in infected cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA.
Human | |
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Gene Name: | APOBEC3B |
Uniprot: | Q9UH17 |
Entrez: | 9582 |
Belongs to: |
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cytidine and deoxycytidylate deaminase family |
APOBEC1L; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B; ARCD3; ARP4; bK150C2.2; cytidine deaminase; DJ742C19.2; EC 3.5.4; EC 3.5.4.-; FLJ21201; phorbolin 3; Phorbolin-1-related protein; phorbolin-2/3; PHRBNLphorbolin 2; probable DNA dC->dU-editing enzyme APOBEC-3B
Mass (kDA):
45.924 kDA
Human | |
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Location: | 22q13.1 |
Sequence: | 22; NC_000022.11 (38982347..38992779) |
Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues.
Nucleus.
PMID: 10469298 by Madsen P.P., et al. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.
PMID: 16060832 by Rose K.M., et al. Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G.