This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about DNA dC->dU-editing enzyme APOBEC-3A.
Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA.
Human | |
---|---|
Gene Name: | APOBEC3A |
Uniprot: | P31941 |
Entrez: | 200315 |
Belongs to: |
---|
cytidine and deoxycytidylate deaminase family |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ARP3; bK150C2.1; EC 3.5.4; EC 3.5.4.-; phorbolin 1; phorbolin-1; PHRBNprobable DNA dC->dU-editing enzyme APOBEC-3A
Mass (kDA):
23.012 kDA
Human | |
---|---|
Location: | 22q13.1 |
Sequence: | 22; NC_000022.11 (38957609..38963184) |
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.
Nucleus. Cytoplasm.
If you're looking to use Boster Bio, you've come to the right site. Here you'll find helpful suggestions and troubleshooting tips as well as information on APOBEC3A. Keep reading to learn how the APOBEC3A marker can assist you in achieving your goals. And while you're at it be sure to read our Boster Bio benefits guide.
Numerous benefits are provided by the APOBEC3A Marker. The UI provides a similar activity to APOBEC3A. A rise in activity was observed at NVC triloop cytosines that are on the template of the lagging strand. The activity was greater than that at similar non-hairpin TpC sites. It could enhance your life. You can download the Source Data file for this APOBEC3A Marker.
APOBEC3A mutations are among the most frequent cancer mutations. In recent years they have been thoroughly researched. Different aspects of these mutations have been discovered and include strand-coordinated clusters of mutations and kataegis. APOBEC enzyme mutations have been found to alter LGST and hairpin loops of DNA. These factors contribute to the growth of cancers.
APOBEC3A protein helps in the removal of foreign DNA from human cells. Additionally it is involved in a process known as antiviral resistance. Its function in preventing HIV infection is well-known. Other types of DNA structure might affect the APOBEC activity. These findings are encouraging for research into HIV prevention and treatment. The APOBEC3A Marker enables doctors to recognize diseases and stop them from causing permanent damage.
APOBEC3A expression was linked to better prognosis in cancer cells. This gene is expressed in various types of cancer including ovarian and breast cancer. APOBEC3A, however, isn't present in breast cancers that are estrogen receptor positive. Higher levels of APOBEC3B expression in breast cancer were linked to lower overall survival rates and shorter periods of disease-free survival. This gene could also contribute to better interaction between B cells and T cells in cancer patients.
APOBEC3A expression levels are usually increased in tumor cells. Based on the APOBEC mutations signature, it is difficult to identify tumors with high levels of APOBEC3A/B. Although mutated APOBEC3A/B expression in tumors is often difficult to predict however, APOBEC mutations remain evidence in cancer cells. The levels of APOBEC mutations can be transient , and then go to normal following an event that causes mutation.
Any method can be used to determine the level of expression of APOBEC3. There are several reagents for the detection of proteins, including antibody-based methods such as western blot, flow cytometry as well as immunofluorescence and enzyme-linked immunosorbent assay. Non-antibody methods include protein analysis, interaction binding and enzyme fragment complementation.
PMID: 10469298 by Madsen P.P., et al. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.
PMID: 11863358 by Jarmuz A., et al. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.