Protein APCDD1 Antibodies

AND APCDD1 ELISA kits, Protein APCDD1 Proteins

Many biological assays use antibodies to detect Protein APCDD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein APCDD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein APCDD1 antibodies...

We validate the specificity of these antibodies to Protein APCDD1 by testing them on tissues known to express APCDD1 positively and negatively. Browse below to find the APCDD1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: ZNF480

APCDD1 Infographic by Boster Bio

All APCDD1 Products

Product

Figures

Specificity

Applications

Price

APCDD1 (NM_153000) Human Recombinant Protein

$1249
Cat # PROTQ8J025
20 µg

APCDD1 (NM_153000) Human Over-expression Lysate

Human

$628
Cat # LS147495
100 µg

APCDD1 Overview

Facts about Protein APCDD1.

APCDD1 3D structure. Source: alphafold

Protein APCDD1 (APCDD1)

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin.

May act through its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.

Gene Information

Human
Gene Name:	APCDD1
Uniprot:	Q8J025
Entrez:	147495

Family

Belongs to:

APCDD1 family

Alternative Names

Adenomatosis polyposis coli down-regulated 1 protein; adenomatosis polyposis coli down-regulated 1; APC Down Regulated 1; APCDD1; B7323; DRAPC1; HYPT1; protein APCDD1

Molecular Weight

Mass (kDA):
58.797 kDA

Genomic Context


Human

Location:	18p11.22
Sequence:	18; NC_000018.10 (10454635..10489949)

Tissue Specificity

Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Malignant Neoplasms
Nervousness
Hypotrichosis
Hypotrichosis Simplex
Polyposis
Cell Transformation, Neoplastic
Lung Neoplasms
Non-small Cell Lung Carcinoma
Complete Trisomy 18 Syndrome
Colonic Neoplasms
Malignant Tumor Of Colon
Down Syndrome

Hair Diseases
Aneuploidy
Malignant Neoplasm Of Lung
Carcinogenesis
Nephroblastoma
Adenomatous Polyposis Coli
Neoplasms

Interacting Proteins

LRP5
WNT3A

Pathways

Localization
Methylation
Osteoclast Differentiation
Axis Specification
Osteoblast Differentiation
Gliogenesis
Generation Of Neurons

Dna Methylation
Neurogenesis

PTMs

Methylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APCDD1

References

PMID: 12384519 by Takahashi M., et al. Isolation of a novel human gene, APCDD1, as a direct target of the b- catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis.

PMID: 20393562 by Shimomura Y., et al. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex.