AP2A1 Antibodies

AND AP2A1 ELISA kits, AP2A1 Proteins

Many biological assays use antibodies to detect AP2A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AP2A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AP2A1 antibodies...

We validate the specificity of these antibodies to AP2A1 by testing them on tissues known to express AP2A1 positively and negatively. Browse below to find the AP2A1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AP2A1 Infographic by Boster Bio

All AP2A1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Alpha-Adaptin AP2A1 Antibody (Monoclonal, 100/2)

1 Q&As

Human, Mouse, Rat

$370
Cat # MA1105
100 μg/vial

Anti-Alpha1 adaptin AP2A1 Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M08806
100 μl

Anti-AP-2 complex subunit alpha-1 AP2A1 Antibody

Human, Mouse, Rat

$405
Cat # A08806
100ul

Anti-alpha Adaptin/AP2A1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A08806-1
100 μg/vial

AP2A1 Overview

Facts about AP-2 complex subunit alpha-1.

AP2A1 3D structure. Source: alphafold

AP-2 complex subunit alpha-1 (AP2A1)

Part of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways.

Adaptor protein complexes are vesicle coat components and seem to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis where cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) that are destined for fusion with the early endosome.

Gene Information

Human
Gene Name:	AP2A1
Uniprot:	O95782
Entrez:	160

Family

Belongs to:

adaptor complexes large subunit family

Alternative Names

100 kDa coated vesicle protein A; Adapter-related protein complex 2 alpha-1 subunit; Adaptor protein complex AP-2 subunit alpha-1; adaptor-related protein complex 2, alpha 1 subunit; ADTAAAP2-ALPHA; alpha1-adaptin; Alpha-adaptin A; AP-2 complex subunit alpha-1; CLAPA1adaptin, alpha A; Clathrin assembly protein complex 2 alpha-A large chain; clathrin-associated/assembly/adaptor protein, large, alpha 1; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit

Molecular Weight

Mass (kDA):
107.546 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (49767001..49807114)

Tissue Specificity

Isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.

Subcellular Localizations

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.

Diseases

Immunologic Deficiency Syndromes
Hiv Infections
Rhabdomyosarcoma
Glioma
Enterovirus Infections

Pathways

Endocytosis
Clathrin-mediated Endocytosis
Transport
Notch Signaling Pathway
Cell Proliferation
Mitosis
Pathogenesis
Viral Replication

Localization
Nuclear Transport

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AP2A1

References

PMID: 12036598 by Scorilas A., et al. Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.

PMID: 11532990 by Waelter S., et al. The huntingtin interacting protein HIP1 is a clathrin and alpha- adaptin-binding protein involved in receptor-mediated endocytosis.