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- Table of Contents
Facts about Proline-rich AKT1 substrate 1.
Amino acid-signaling into mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complicated and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.
Mouse | |
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Gene Name: | Akt1s1 |
Uniprot: | Q9D1F4 |
Entrez: | 67605 |
Belongs to: |
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No superfamily |
40 kDa; AKT1 substrate 1 (proline-rich); AKT1S1; Lobe; MGC2865; PRAS40; proline-rich AKT1 substrate 1,40 kDa proline-rich AKT substrate
Mass (kDA):
27.483 kDA
Mouse | |
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Location: | 7|7 B3 |
Sequence: | 7; |
PMID: 14973226 by Saito A., et al. Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
PMID: 16397181 by Saito A., et al. Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.