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AKT1 Antibodies
AND AKT1 ELISA kits, AKT1 Proteins
Many biological assays use antibodies to detect AKT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKT1 antibodies...
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AKT1 Infographic by Boster Bio
All AKT1 Products
Product
Figures
Specificity
Applications
Price
Anti-PKB Alpha Akt1 Antibody (Monoclonal, PKB-175)
16 Citations 16 Q&As
Chicken, Human, Mouse, Rat
WB
$370
Cat # MA1085
100 μg/vial
Cat # MA1085
100 μg/vial
Anti-Phospho-AKT1 (T450) Rabbit Monoclonal Antibody
14 Citations 4 Q&As
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # P00024-2
100 μl
Cat # P00024-2
100 μl
Anti-Phospho-AKT1 (S129) Rabbit Monoclonal Antibody
14 Citations 3 Q&As
Human, Mouse, Rat
WB
$370
Cat # P00024-3
100 μl
Cat # P00024-3
100 μl
Anti-Phospho-AKT1 (S124) Rabbit Monoclonal Antibody
14 Citations 4 Q&As
Human, Mouse, Rat
IP, WB
$370
Cat # P00024-4
100 μl
Cat # P00024-4
100 μl
Anti-Phospho-Akt (Ser473) AKT1 Rabbit Monoclonal Antibody
21 Citations 4 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00024-5
100 μl
Cat # P00024-5
100 μl
Anti-Akt phospho S473 Monoclonal Antibody
15 Citations 15 Q&As
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, WB
$646
Cat # MP00024
100ug
Cat # MP00024
100ug
Anti-AKT1 Monoclonal Antibody
17 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00024-1
100 μl
Cat # M00024-1
100 μl
Anti-Phospho-Akt (Ser473) AKT1 Rabbit Monoclonal Antibody, Clone#RM251
4 Citations 16 Q&As
Human
IHC, WB
$431
Cat # P00024-6
100ul
Cat # P00024-6
100ul
Anti-Akt1 Rabbit Monoclonal Antibody, Clone#RM252
2 Citations 16 Q&As
Human
IHC, WB
$431
Cat # M00024-3
100ul
Cat # M00024-3
100ul
Anti-AKT (PH domain) AKT1 Rabbit Monoclonal Antibody, Clone#RM316
2 Citations 16 Q&As
Human
IHC, WB
$431
Cat # M00024-4
100uL
Cat # M00024-4
100uL
Anti-Akt (E17K Mutant) AKT1 Rabbit Monoclonal Antibody, Clone#RM336
1 Citations 5 Q&As
Human
ELISA, IHC, WB
$506
Cat # M00024-2
50ug
Cat # M00024-2
50ug
Human, Mouse, Rat
ELISA
$480
Cat # EKC1022
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1022
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1927
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1927
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2015
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2015
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2139
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2139
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2140
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2140
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2141
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2141
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2212
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2212
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2347
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2347
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2557
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2557
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2635
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2635
1 kit, containing two 96-well plates and all necessary reagents
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00024
100 µl
Cat # M00024
100 µl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00024-7
100 µl/vial
Cat # M00024-7
100 µl/vial
AKT1 Overview
Facts about RAC-alpha serine/threonine-protein kinase.
RAC-alpha serine/threonine-protein kinase (AKT1)
This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported up to now, but for most of them, no isoform specificity has been reported.
AKT accounts for the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 sugar transporter to the cell surface. Phosphorylation of PTPN1 in'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | AKT1 |
| Uniprot: | P31749 |
| Entrez: | 207 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
AKT serine/threonine kinase 1; AKT; Akt1; AKT1m; CWS6; EC 2.7.11; EC 2.7.11.1; PKB alpha; PKB; PKBMGC99656; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; rac protein kinase alpha; RAC; RAC-alpha serine/threonine-protein kinase; RAC-alpha; RAC-PK-alpha; RACPKB-ALPHA; Serine-Threonine Protein Kinase ; v-akt murine thymoma viral oncogene homolog 1; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1
Molecular Weight
Mass (kDA):
55.686 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.33 |
| Sequence: | 14; NC_000014.9 (104769349..104795748, complement) |
Tissue Specificity
Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Subcellular Localizations
Cytoplasm. Nucleus. Cell membrane. Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Prostatic Neoplasms
- Insulin Resistance
- Leukemia
Pathways
- Cell Proliferation
- Cell Death
- Cell Growth
- Cell Cycle
- Angiogenesis
- Localization
- Pathogenesis
- Secretion
- Transport
- Cell Migration
- Induction Of Apoptosis
- Cell Cycle Arrest
- Translation
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Myristoylation
- Ubiquitination
- Oxidation
- Methylation
- Reduction
- Glycosylation
- Acetylation
Research Areas
- Angiogenesis
- Apoptosis
- Autophagy
- Cancer
- Cellular Markers
- Growth and Development
- Hypoxia
- mTOR Pathway
- Neuronal Cell Markers
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKT1
bosterbio.com/bosterbio-gene-info-cards/AKT1
References
PMID: 1851997 by Jones P.F., et al. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.
PMID: 11508278 by Matsubara A., et al. Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.
30 Publications of Boster AKT1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/etm.2021.9797, MicroRNA‑185 inhibits the proliferation and migration of HaCaT keratinocytes b...
- PubMed ID: 10.3748/wjg.v25.i40.6063, Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation ...
- PubMed ID: 10.1155/2019/1760184, 11C-Labeled Pictilisib (GDC-0941) as a Molecular Tracer Targeting Phosphatidylin...
- PubMed ID: 10.1016/j.jep.2020.113407, Sesquiterpene lactones; Damsin and neoambrosin suppress cytokine-mediated inflam...
- PubMed ID: 10.1016/j.brainres.2021.147508, The calcimimetic R-568 attenuates subarachnoid hemorrhage-induced vasospasm thro...
- PubMed ID: 10.1002/ddr.21821, Investigating function of long noncoding RNA of HOTAIRM1 in progression of SKOV3...
- PubMed ID: 31787861, Han N,Jiang Y,Gai Y,Liu Q,Yuan L,Wang Y,Li M,Zhang Y,Lan X.11C-Labeled Pictilisi...
- PubMed ID: 33930376, Güleç İ, Şengelen A,Karagöz-Güzey F,Önay-Uçar E,Eren B,Vahabova G,Karaca...
- PubMed ID: 33654381, Xu Y,Chen W,Chen Z,Huang M,Yang F,Zhang Y.Mechanism of Action of Xiaoyao San in ...
- PubMed ID: 33581257, Qu K,Cha H, Ru Y,Que H,Xing M.Buxuhuayu Decoction Accelerates Angiogenesis by Ac...
- PubMed ID: -, Lu Kong,Yongya Wu,Wangcheng Hu,Lin Liu,Yuying Xue,Geyu Liang,Mechanisms underlyi...
- PubMed ID: 33382670, Chen H,Sheng H,Zhao Y,Zhu G.Piperine Inhibits Cell Proliferation and Induces Apo...
- PubMed ID: 32729224, Xiao L,Zhang H,Yang X,Mahati S,Wu G,Xiaheding Y,Bao YX,Xiao H.Role of phosphatid...
- PubMed ID: 31566725, Ji F,Wang Y,Yuan J,Wu Q,Wang J,Liu D.The potential role of stromal cell-derived ...
- PubMed ID: 18694621, A small interfering RNA targeting osteopontin as gastric cancer therapeutics
- PubMed ID: 25738369, Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and s...
- PubMed ID: 29021761, Protective Effects of Sodium (?)-5-Bromo-2-(%u03B1-Hydroxypentyl) Benzoate in a ...
- PubMed ID: 26550236, Vibration exercise decreases insulin resistance and modulates the insulin signal...
- PubMed ID: 29997505, Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through So...
- PubMed ID: 27456341, Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signal...
- PubMed ID: 27279698, Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage A...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page