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- Table of Contents
Facts about A-kinase anchor protein 8-like.
May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899).
Human | |
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Gene Name: | AKAP8L |
Uniprot: | Q9ULX6 |
Entrez: | 26993 |
Belongs to: |
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AKAP95 family |
A kinase (PRKA) anchor protein 8-like; AKAP8-like protein; HA95; HAP95 DKFZp434L0650; helicase A-binding protein 95 kDa; Homologous to AKAP95 protein; HRIHFB2018; NAKAP; NAKAP95 A-kinase anchor protein 8-like; neighbor of A kinase anchoring protein 95; Neighbor of AKAP95; Neighbor of A-kinase-anchoring protein 95
Mass (kDA):
71.64 kDA
Human | |
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Location: | 19p13.12 |
Sequence: | 19; NC_000019.10 (15380050..15418988, complement) |
Ubiquitously expressed. Expressed in the brain cortex (at protein level).
Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm. Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601).
PMID: 10697960 by Seki N., et al. cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region.
PMID: 10761695 by Orstavik S., et al. Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95.