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- Table of Contents
Facts about RING finger protein 11.
TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of this TNF- or LPS-mediated activation of NF-kappa-B.
Human | |
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Gene Name: | RNF11 |
Uniprot: | Q9Y3C5 |
Entrez: | 26994 |
Belongs to: |
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No superfamily |
CGI-123; MGC51169; ring finger protein 11; RNF11; SID1669; Sid1669p
Mass (kDA):
17.444 kDA
Human | |
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Location: | 1p32.3 |
Sequence: | 1; NC_000001.11 (51236273..51273447) |
Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines.
Early endosome. Recycling endosome. Cytoplasm. Nucleus. Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1.
PMID: 10673045 by Seki N., et al. Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein.
PMID: 16123141 by Connor M.K., et al. Molecular characterization of ring finger protein 11.