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- Table of Contents
Facts about A-kinase anchor protein 8.
Recruits condensin complex subunit NCAPD2 into chromosomes necessary for chromatin condensation; the function seems to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to ease cell cycle progression (PubMed:14641107).
Human | |
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Gene Name: | AKAP8 |
Uniprot: | O43823 |
Entrez: | 10270 |
Belongs to: |
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AKAP95 family |
A kinase (PRKA) anchor protein 8; AKAP-8; AKAP-95 AKAP 95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; DKFZp586B1222
Mass (kDA):
76.108 kDA
Human | |
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Location: | 19p13.12 |
Sequence: | 19; NC_000019.10 (15353385..15379787, complement) |
Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells.
Nucleus. Nucleus matrix. Nucleus, nucleolus. Cytoplasm. Associated with the nuclear matrix in interphase and redistributes mostly to chromatin at mitosis. However, mitotic chromatin localization has been questioned. Upon nuclear reassembly at the end of mitosis, is sequestered into the daughter nuclei where it re-acquires an interphase distribution. Localized to the nucleolus in interphase. Colocalizes with GJA1 at the nuclear membrane specifically during cell cycle G1/S phase.
This Boster Bio review will explore the AKAP8 Marker. It covers its applications, side effects, and availability. This review will give you the information you need to make an informed decision. If you're interested in trying this product, please keep reading! It's definitely worth checking out. You'll be glad you did! We hope this review has been helpful. Please don't hesitate to leave your comments below!
The AKAP8 gene is important for alternative splicing. Scientists attach a fluorescent marker to the gene to identify where it is in cells. In addition, AKAP8 interacts with hnRNPM, an enzyme involved in transcription and DNA replication. It also plays a role in protein translation and interaction with tRNA. Here are a few of the best uses for the AKAP8 gene marker.
The AKAP8 gene product is a nuclear matrix protein and is part of the family of anchor proteins whose main role is to recruit signaling molecules to specific subcellular locations. These proteins are also known as AKAPs, as they contain a domain that binds the RII alpha subunit of the PKA kinase. In addition to being a nuclear matrix protein, AKAP8 also has a crucial role in mitotic progression.
The AKAP8 marker is an important regulator of the cell cycle and plays a pivotal role in regulating the expression of genes that regulate the respiratory tract. This gene interacts with several proteins during interphase, including MCM2 and RSK1. It inhibits DNA replication during both the initiation and elongation phases of the cell cycle. Although its function in the body is unclear, it may be involved in airway diseases.
The AKAP family of proteins are known to play an important role in cancer development. Some members of the AKAP gene family, including AKAP8, have been linked to tumor suppressive functions in various cancers. In addition, polymorphisms of the AKAP10 gene have been associated with increased risk of familial breast cancer. AKAP8 gene mutations are also associated with an increased risk of colorectal cancer.
AKAP8 is a regulator of alternative splicing. Scientists attach fluorescent markers to the gene to show where it is located. In addition, this gene interacts with DNA polymerase and RNA polymerase, two key proteins involved in protein translation and replication. Cancer cells cannot multiply without Ezrin phosphorylation. Therefore, removing Ezrin from the body may lead to an increased risk of lung cancer.
AKAP8 is involved in regulating cell division, as well as participating in the signaling pathway. It also functions as a scaffolding protein in the cell cycle, anchoring and coordinating various signaling components. Activation of AKAP inhibits the activity of this protein. When the gene is suppressed, cells will not be able to perform chromosome segregation. This can lead to defects in chromosome segregation, such as tripolar spindles.
The AKAP8 marker is highly expressed in human epithelial cells. It is expressed at higher levels in mesenchymal cells than in epithelial cells. We determined the availability of the AKAP8 marker in metagenes by analyzing the protein's binding to the gene's exons. The protein is significantly more abundant in the introns of epithelial cells, but this difference does not necessarily suggest that AKAP8 regulates alternative splicing directly in these tissues.
The availability of the AKAP8 marker may influence tumorigenesis by determining the presence of the hnRNPM protein CLSTN1. The AKAP8 gene region binds hnRNPM with the highest abundance. It is an essential protein for RNA metabolism. The AKAP8 gene is a potential candidate for targeted gene therapy. Although it is still in its early stages, it has shown remarkable promise in many cancer-related research studies.
The AKAP8 gene regulates EMT in a state-specific manner. In addition to the role it plays in EMT, it also regulates the expression of alternative splicing factors. Furthermore, the AKAP8 gene product is known to affect the expression of RNA by different cells. This means that it has a direct impact on cancer-related genes. When the gene product is depleted, it promotes the EMT phenotype.
AKAP4 is also associated with breast cancer and other forms of breast cancer. Moreover, AKAP3 has been found to be important in ovarian and colorectal cancer cells. AKAP8 is a protein that interacts with minichromosome maintenance protein 2 (MCM2). Its disruption abolished DNA replication in HeLa cells. The AKAP8 gene is involved in regulating the expression of several epithelial markers, such as g-catenin and E-cadherin.
PMID: 9473338 by Eide T., et al. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95.
PMID: 10601332 by Collas P., et al. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis.