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AK2 Antibodies
AND AK2 ELISA kits, AK2 Proteins
Many biological assays use antibodies to detect AK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AK2 antibodies...
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AK2 Infographic by Boster Bio
All AK2 Products
Product
Figures
Specificity
Applications
Price
Enzyme Activity, SDS-PAGE
$250
Cat # PROTP54819
Starting from 20ug
Cat # PROTP54819
Starting from 20ug
Human, Mouse, Zebrafish
Flow Cytometry, IHC-P, WB
$299
Cat # M04253
50 µl
Cat # M04253
50 µl
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M04253-1
100 μl/vial
Cat # M04253-1
100 μl/vial
AK2 Overview
Facts about Adenylate kinase 2, mitochondrial.
Adenylate kinase 2, mitochondrial (AK2)
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an essential role in cellular energy homeostasis and in adenine nucleotide metabolism.
Adenylate kinase activity is critical for regulation of the phosphate utilization as well as the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | AK2 |
| Uniprot: | P54819 |
| Entrez: | 204 |
Family
| Belongs to: |
|---|
| adenylate kinase family |
Alternative Names
adenylate kinase 2; adenylate kinase 2, mitochondrial; adenylate kinase isoenzyme 2, mitochondrial; ADK2; AK 2; ATP-AMP transphosphorylase 2; EC 2.7.4; EC 2.7.4.3
Molecular Weight
Mass (kDA):
26.478 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.1 |
| Sequence: | 1; NC_000001.11 (33007940..33036911, complement) |
Tissue Specificity
Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
Subcellular Localizations
Mitochondrion intermembrane space.
Diseases
- Von Willebrand Disease
- Tissue Adhesions
- Severe Combined Immunodeficiency
- Congenital Abnormality
- Congenital Combined Immunodeficiency
- Reticular Dysgenesis
- Immunologic Deficiency Syndromes
- Neoplasms
- Conjunctival Diseases
- Nervousness
- Thrombosis
- Neoplasm Metastasis
- Severe Congenital Neutropenia
Pathways
- Cell Differentiation
- Platelet Aggregation
- Localization
- Secretion
- Platelet Activation
- Regeneration
- Pathogenesis
- Transport
- Cell Cycle
- Cell Growth
- Neutrophil Differentiation
- Hemostasis
- Cell Adhesion
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AK2
bosterbio.com/bosterbio-gene-info-cards/AK2
References
PMID: 8843353 by Lee Y., et al. Cloning and characterization of cDNA for human adenylate kinase 2A.
PMID: 9504408 by Lee Y., et al. Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues.