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- Table of Contents
Facts about Cytosolic carboxypeptidase 1.
Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins like MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, although it's unable to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Human | |
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Gene Name: | AGTPBP1 |
Uniprot: | Q9UPW5 |
Entrez: | 23287 |
Belongs to: |
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peptidase M14 family |
ATP/GTP binding protein 1; ATP/GTP-binding protein 1; CCP1; DKFZp686M20191; EC 3.4.17; EC 3.4.17.-; KIAA1035NNA1cytosolic carboxypeptidase 1; Nervous system nuclear protein induced by axotomy protein 1 homolog; Nna1
Mass (kDA):
138.448 kDA
Human | |
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Location: | 9q21.33 |
Sequence: | 9; NC_000009.12 (85546539..85742029, complement) |
Cytoplasm. Cytoplasm, cytosol. Nucleus. Mitochondrion. Localizes in both the cytoplasm and nuclei of interphase and dividing cells.
PMID: 23085998 by Rodriguez de la Vega Otazo M., et al. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).
PMID: 30420557 by Shashi V., et al. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.