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- Table of Contents
Facts about Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2.
Aids the coupling of metabotropic glutamate receptor 1 (GRM1) into cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. .
Rat | |
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Gene Name: | Agap2 |
Uniprot: | Q8CGU4 |
Entrez: | 65218 |
Belongs to: |
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centaurin gamma-like family |
AGAP-2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin, gamma 1; centaurin-gamma-1; CENTG1; cnt-g1; FLJ16430; GGAP2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; KIAA0167; Phosphatidylinositol-3-kinase enhancer; phosphoinositide 3-kinase enhancer; PIKEArf GAP with GTP-binding protein-like, ANK repeat and PH domains 2
Mass (kDA):
124.438 kDA
Rat | |
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Location: | 7q22 |
Sequence: | 7; |
Present in cortex, hippocampus and olfactory bulb but absent in cerebellum (at protein level).
PMID: 14528310 by Rong R., et al. PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.
PMID: 11136977 by Ye K., et al. PIKE: a nuclear GTPase that enhances PI3kinase activity and is regulated by protein 4.1N.